A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression
about
Getting to S: CDK functions and targets on the path to cell-cycle commitmentTFIIH: New Discoveries Regarding its Mechanisms and Impact on Cancer TreatmentCDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction pointMycobacterium tuberculosis arrests host cycle at the G1/S transition to establish long term infectionAn inhibitor's-eye view of the ATP-binding site of CDKs in different regulatory states.Targeting transcription regulation in cancer with a covalent CDK7 inhibitorThe CDK4/CDK6 inhibitor PD0332991 paradoxically stabilizes activated cyclin D3-CDK4/6 complexes.Pause, play, repeat: CDKs push RNAP II's buttons.How the cell cycle impacts chromatin architecture and influences cell fate.The roles and therapeutic potential of cyclin-dependent kinases (CDKs) in sarcoma.Cyclin-dependent kinase 7 controls mRNA synthesis by affecting stability of preinitiation complexes, leading to altered gene expression, cell cycle progression, and survival of tumor cells.CDK1 structures reveal conserved and unique features of the essential cell cycle CDK.Improving the Understanding of Pathogenesis of Human Papillomavirus 16 via Mapping Protein-Protein Interaction Network.JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21.CDK4 phosphorylation status and a linked gene expression profile predict sensitivity to palbociclib.CDK7 and miR-210 Co-regulate Cell-Cycle Progression of Neural Progenitors in the Developing Neocortex.The CDK-activating kinase Cdk7: taking yes for an answer.Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors.Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression.CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment.The essential and multi-functional TFIIH complex.The Temporal Regulation of S Phase Proteins During G1.Xeroderma Pigmentosum Group D (XPD) Inhibits the Proliferation Cycle of Vascular Smooth Muscle Cell (VSMC) by Activating Glycogen Synthase Kinase 3β (GSK3β)Structural insights into the functional diversity of the CDK-cyclin family
P2860
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P2860
A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression
description
2013 nî lūn-bûn
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2013年の論文
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2013年論文
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2013年論文
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2013年論文
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name
A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression
@en
type
label
A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression
@en
prefLabel
A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression
@en
P2093
P2860
P1433
P1476
A Cdk7-Cdk4 T-loop phosphorylation cascade promotes G1 progression
@en
P2093
Alexander Hirschi
Chao Zhang
Karl A Merrick
Kevan M Shokat
Miriam Merzel Schachter
Robert P Fisher
Seth M Rubin
Stéphane Larochelle
P2860
P304
P356
10.1016/J.MOLCEL.2013.04.003
P577
2013-04-01T00:00:00Z