Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents.
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A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagyGuidelines for the use and interpretation of assays for monitoring autophagyPresenilin-1 regulates the expression of p62 to govern p62-dependent tau degradationThe Rho-family GEF Asef2 activates Rac to modulate adhesion and actin dynamics and thereby regulate cell migrationAkt and autophagy cooperate to promote survival of drug-resistant gliomaThe autophagy-lysosomal system in subarachnoid haemorrhageChloroquine and hydroxychloroquine for cancer therapyCapitalizing on the autophagic response for treatment of liver disease caused by alpha-1-antitrypsin deficiency and other genetic diseasesMitophagy: mechanisms, pathophysiological roles, and analysisAutophagy and neurodegenerationAutophagy in hepatitis C virus-host interactions: potential roles and therapeutic targets for liver-associated diseasesAutophagy modulation as a potential therapeutic target for diverse diseasesTargeting autophagy for the treatment of liver diseasesTumor cell autophagy as an adaptive response mediating resistance to treatments such as antiangiogenic therapyAutophagy suppresses RIP kinase-dependent necrosis enabling survival to mTOR inhibitionRedox modification of proteins as essential mediators of CNS autophagy and mitophagy.Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicityNitazoxanide stimulates autophagy and inhibits mTORC1 signaling and intracellular proliferation of Mycobacterium tuberculosisInduction of autophagy is an early response to gefitinib and a potential therapeutic target in breast cancerThe synergistic effect of everolimus and chloroquine on endothelial cell number reduction is paralleled by increased apoptosis and reduced autophagy occurrenceGambogenic acid kills lung cancer cells through aberrant autophagyp62/SQSTM1 accumulation in squamous cell carcinoma of head and neck predicts sensitivity to phosphatidylinositol 3-kinase pathway inhibitorsAutophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injuryChloroquine sensitizes breast cancer cells to chemotherapy independent of autophagyNovel quantitative autophagy analysis by organelle flow cytometry after cell sonication.Chloroquine enhances the cytotoxicity of topotecan by inhibiting autophagy in lung cancer cellsInduction of autophagy contributes to crizotinib resistance in ALK-positive lung cancerAutophagy: cerebral home cooking.WNT/β-catenin signaling regulates mitochondrial activity to alter the oncogenic potential of melanoma in a PTEN-dependent manner.Role of autophagy in suppression of inflammation and cancer.Role of inositol trisphosphate receptors in autophagy in DT40 cells.Ibrutinib, a Bruton's tyrosine kinase inhibitor, exhibits antitumoral activity and induces autophagy in glioblastoma.Inhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape.Synergistic signaling of tumor cell invasiveness by hepatocyte growth factor and hypoxia.Activity of any class IA PI3K isoform can sustain cell proliferation and survival.Autophagy inhibition and antimalarials promote cell death in gastrointestinal stromal tumor (GIST).Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition.Combination of AKT inhibition with autophagy blockade effectively reduces ascites-derived ovarian cancer cell viability.Cellular stress induced by resazurin leads to autophagy and cell death via production of reactive oxygen species and mitochondrial impairmentPerifosine induces protective autophagy and upregulation of ATG5 in human chronic myelogenous leukemia cells in vitro.
P2860
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P2860
Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Akt inhibition promotes autoph ...... mors to lysosomotropic agents.
@en
type
label
Akt inhibition promotes autoph ...... mors to lysosomotropic agents.
@en
prefLabel
Akt inhibition promotes autoph ...... mors to lysosomotropic agents.
@en
P2093
P2860
P356
P1476
Akt inhibition promotes autoph ...... mors to lysosomotropic agents.
@en
P2093
Ann De Mazière
Brian B Lee
Christine Orr
Daniel C Gray
David P Davis
Howard M Stern
Janet Y Tien
Klaus P Hoeflich
P2860
P304
P356
10.1083/JCB.200801099
P407
P577
2008-10-01T00:00:00Z