Beta-globin nonsense mutation: deficient accumulation of mRNA occurs despite normal cytoplasmic stability.
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Human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase geneMolecular genetics of neurofibromatosis type 1 (NF1)Mutations in the human lambda5/14.1 gene result in B cell deficiency and agammaglobulinemiaThe molecular basis of HEXA mRNA deficiency caused by the most common Tay-Sachs disease mutationMaternal acute fatty liver of pregnancy associated with fetal trifunctional protein deficiency: molecular characterization of a novel maternal mutant alleleA gene-targeted mouse model for familial hypobetalipoproteinemia. Low levels of apolipoprotein B mRNA in association with a nonsense mutation in exon 26 of the apolipoprotein B geneDual mechanisms for the low plasma levels of truncated apolipoprotein B proteins in familial hypobetalipoproteinemia. Analysis of a new mouse model with a nonsense mutation in the Apob geneRapid deadenylation triggered by a nonsense codon precedes decay of the RNA body in a mammalian cytoplasmic nonsense-mediated decay pathwayFrameshift mutations in the v-src gene of avian sarcoma virus act in cis to specifically reduce v-src mRNA levels.Intranuclear degradation of nonsense codon-containing mRNAThe tripartite leader sequence of subgroup C adenovirus major late mRNAs can increase the efficiency of mRNA export.Identification of an additional gene required for eukaryotic nonsense mRNA turnover.A premature termination codon interferes with the nuclear function of an exon splicing enhancer in an open reading frame-dependent mannerNonsense-mediated decay of human HEXA mRNA.Unspliced precursors of NMD-sensitive β-globin transcripts exhibit decreased steady-state levels in erythroid cellsPremature termination codons do not affect the rate of splicing of neighboring introns.When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells.A high incidence of BRCA1 mutations in 20 breast-ovarian cancer families.A splicing-dependent regulatory mechanism that detects translation signals.Evidence to implicate translation by ribosomes in the mechanism by which nonsense codons reduce the nuclear level of human triosephosphate isomerase mRNA.Process or perish: quality control in mRNA biogenesis.T cell receptor (TCR) mini-gene mRNA expression regulated by nonsense codons: a nuclear-associated translation-like mechanismA single-base-pair deletion in the beta-glucuronidase gene accounts for the phenotype of murine mucopolysaccharidosis type VIIIdentification and characterization of a sequence motif involved in nonsense-mediated mRNA decayContext effects on misreading and suppression at UAG codons in human cells.Effects of nonsense mutations on nuclear and cytoplasmic adenine phosphoribosyltransferase RNA.Characterization of cis-acting sequences and decay intermediates involved in nonsense-mediated mRNA turnover.Determination of mRNA fate by different RNA polymerase II promoters.Rous sarcoma virus RNA stability requires an open reading frame in the gag gene and sequences downstream of the gag-pol junctionIntrons are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundanceNonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping.Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae.Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life.Nonsense codons can reduce the abundance of nuclear mRNA without affecting the abundance of pre-mRNA or the half-life of cytoplasmic mRNA.Premature termination mutations in FBN1: distinct effects on differential allelic expression and on protein and clinical phenotypes.RNA surveillance: molecular approaches in transcript quality control and their implications in clinical diseases.Low cytoplasmic mRNA levels of immunoglobulin kappa light chain genes containing nonsense codons correlate with inefficient splicing.Nonsense-mediated decay of glutathione peroxidase 1 mRNA in the cytoplasm depends on intron position.Human gene mutations affecting RNA processing and translation.Identification of DNA mismatch repair gene mutations in hereditary nonpolyposis colon cancer patients.
P2860
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P2860
Beta-globin nonsense mutation: deficient accumulation of mRNA occurs despite normal cytoplasmic stability.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Beta-globin nonsense mutation: ...... normal cytoplasmic stability.
@en
type
label
Beta-globin nonsense mutation: ...... normal cytoplasmic stability.
@en
prefLabel
Beta-globin nonsense mutation: ...... normal cytoplasmic stability.
@en
P2860
P356
P1476
Beta-globin nonsense mutation: ...... normal cytoplasmic stability.
@en
P2093
Baserga SJ
Benz EJ Jr
P2860
P304
P356
10.1073/PNAS.89.7.2935
P407
P577
1992-04-01T00:00:00Z