Hormone-induced progesterone receptor phosphorylation consists of sequential DNA-independent and DNA-dependent stages: analysis with zinc finger mutants and the progesterone antagonist ZK98299.
about
A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamilyCyclin dependent kinase 2 and the regulation of human progesterone receptor activityPost-translational modifications of the progesterone receptorsProgesterone receptor rapid signaling mediates serine 345 phosphorylation and tethering to specificity protein 1 transcription factors.Partial agonist activity of the progesterone receptor antagonist RU486 mediated by an amino-terminal domain coactivator and phosphorylation of serine400Transcriptional hyperactivity of human progesterone receptors is coupled to their ligand-dependent down-regulation by mitogen-activated protein kinase-dependent phosphorylation of serine 294.Androgens, progestins, and glucocorticoids induce follicle-stimulating hormone beta-subunit gene expression at the level of the gonadotropeHeregulin induces transcriptional activation of the progesterone receptor by a mechanism that requires functional ErbB-2 and mitogen-activated protein kinase activation in breast cancer cells.Estrogen receptor accessory proteins: effects on receptor-DNA interactions.Developmental changes in the expression and compartmentalization of the glucocorticoid receptor in embryonic retinaProgesterone receptors upregulate Wnt-1 to induce epidermal growth factor receptor transactivation and c-Src-dependent sustained activation of Erk1/2 mitogen-activated protein kinase in breast cancer cells.In vivo evidence against the existence of antiprogestins disrupting receptor binding to DNAThe progesterone antagonist RU486 acquires agonist activity upon stimulation of cAMP signaling pathways.Synergistic induction of follicle-stimulating hormone beta-subunit gene expression by gonadal steroid hormone receptors and Smad proteinsIntegration of progesterone receptor action with rapid signaling events in breast cancer models.Progesterone induction of the 11beta-hydroxysteroid dehydrogenase type 2 promoter in breast cancer cells involves coordinated recruitment of STAT5A and progesterone receptor to a distal enhancer and polymerase trackingDifferential and interactive effects of ligand-bound progesterone receptor A and B isoforms on tyrosine hydroxylase promoter activity.A composite intronic element directs dynamic binding of the progesterone receptor and GATA-2.Steroid hormone receptors and their regulation by phosphorylation.Mutational analysis of progesterone receptor functional domains in stable cell lines delineates sets of genes regulated by different mechanisms.Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase 2.Antiprogestins in the induction of labor.Androgen receptor phosphorylation.Control of transcription by steroid hormones.Stoichiometry and site-specific phosphorylation of human progesterone receptor in native target cells and in the baculovirus expression system.Role of phosphorylation on DNA binding and transcriptional functions of human progesterone receptors.Ligand-induced conformational alterations of the androgen receptor analyzed by limited trypsinization. Studies on the mechanism of antiandrogen action.Two types of anti-progestins have distinct effects on site-specific phosphorylation of human progesterone receptor.Interference between progesterone and dioxin signal transduction pathways. Different mechanisms are involved in repression by the progesterone receptor A and B isoforms.Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells.New human breast cancer cells to study progesterone receptor isoform ratio effects and ligand-independent gene regulation.
P2860
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P2860
Hormone-induced progesterone receptor phosphorylation consists of sequential DNA-independent and DNA-dependent stages: analysis with zinc finger mutants and the progesterone antagonist ZK98299.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
Hormone-induced progesterone r ...... ogesterone antagonist ZK98299.
@en
type
label
Hormone-induced progesterone r ...... ogesterone antagonist ZK98299.
@en
prefLabel
Hormone-induced progesterone r ...... ogesterone antagonist ZK98299.
@en
P2093
P2860
P356
P1476
Hormone-induced progesterone r ...... ogesterone antagonist ZK98299.
@en
P2093
A C Eppert
D M Tasset
G S Takimoto
K B Horwitz
P2860
P304
P356
10.1073/PNAS.89.7.3050
P407
P577
1992-04-01T00:00:00Z