Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection
about
siRNA and RNAi optimizationProgress toward in vivo use of siRNAs-IISilencing disease genes in the laboratory and the clinicSynthesis and gene silencing properties of siRNAs containing terminal amide linkages.Improved siRNA/shRNA functionality by mismatched duplex.Effect of siRNA with an asymmetric RNA/dTdT overhang on RNA interference activity.Development of defective and persistent Sendai virus vector: a unique gene delivery/expression system ideal for cell reprogrammingsiRNA repositioning for guide strand selection by human Dicer complexes.Efficient in vivo delivery of siRNA into brain capillary endothelial cells along with endogenous lipoproteinRNA interference approaches for treatment of HIV-1 infectionAsymmetric siRNA: new strategy to improve specificity and reduce off-target gene expression.Suppressive Effect of Constructed shRNAs against Apollon Induces Apoptosis and Growth Inhibition in the HeLa Cell Line.Short non-coding RNA biology and neurodegenerative disorders: novel disease targets and therapeutics.Selection and optimization of asymmetric siRNA targeting the human c-MET gene.Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors.Chemical modification of siRNA.Novel RNA-based strategies for therapeutic gene silencing.RNA interference-based therapeutics for human immunodeficiency virus HIV-1 treatment: synthetic siRNA or vector-based shRNA?Unlocked nucleic acid--an RNA modification with broad potential.Structural diversity repertoire of gene silencing small interfering RNAs.RNA interference trigger variants: getting the most out of RNA for RNA interference-based therapeuticsModified siRNA structure with a single nucleotide bulge overcomes conventional siRNA-mediated off-target silencing.Effect of the guide strand 3'-end structure on the gene-silencing potency of asymmetric siRNA.An intracellular buildup reaction of active siRNA species from short RNA fragments.The siRNA sequence and guide strand overhangs are determinants of in vivo duration of silencing.Tuning RNA Interference by Enhancing siRNA/PAZ Recognition.The sense strand pre-cleaved RNA duplex mediates an efficient RNA interference with less off-target and immune response effects.Effective inhibition of HIV-1 production by short hairpin RNAs and small interfering RNAs targeting a highly conserved site in HIV-1 Gag RNA is optimized by evaluating alternative length formats.The Business of RNAi Therapeutics in 2012Improvement of RNAi activity and strand selectivity of RISC formation by modified siRNA involving intercalators near 5' termini.Designing Tyrosinase siRNAs by Multiple Prediction Algorithms and Evaluation of Their Anti-Melanogenic Effects.Removal of miRNA passenger strandRemoval of siRNA passenger strandCleavage-based removal of the siRNA passenger strand by AGO2Reversed assembly of dyes in an RNA duplex compared with those in DNA.Asymmetric RNA duplexes mediate RNA interference in mammalian cells.AGO2 cleaves passenger strand of duplex siRNAC3PO hydrolyzes cleaved passenger strandExploring PAZ/3'-overhang interaction to improve siRNA specificity. A combined experimental and modeling study.
P2860
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P2860
Effect of asymmetric terminal structures of short RNA duplexes on the RNA interference activity and strand selection
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Effect of asymmetric terminal ...... activity and strand selection
@en
type
label
Effect of asymmetric terminal ...... activity and strand selection
@en
prefLabel
Effect of asymmetric terminal ...... activity and strand selection
@en
P2093
P2860
P50
P356
P1476
Effect of asymmetric terminal ...... activity and strand selection
@en
P2093
Malgorzata Sierant
Shizuyo Sutou
Yasuomi Takagi
P2860
P304
P356
10.1093/NAR/GKN584
P407
P577
2008-09-09T00:00:00Z