Silencing disease genes in the laboratory and the clinic
about
Epigenomics of idiopathic pulmonary fibrosisHydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse BrainAmides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAsActivating frataxin expression by repeat-targeted nucleic acidsEfficacy of a novel class of RNA interference therapeutic agentsAllele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patientsBlockage of the upregulation of voltage-gated sodium channel nav1.3 improves outcomes after experimental traumatic brain injury.Small interfering RNA targeting nerve growth factor alleviates allergic airway hyperresponsiveness.Gold Nanoparticles for BCR-ABL1 Gene Silencing: Improving Tyrosine Kinase Inhibitor Efficacy in Chronic Myeloid Leukemia.Synthesis and biophysical properties of C5-functionalized LNA (locked nucleic acid).C5-alkynyl-functionalized α-L-LNA: synthesis, thermal denaturation experiments and enzymatic stabilityAllele-selective inhibition of mutant atrophin-1 expression by duplex and single-stranded RNAs.Enhancer RNA facilitates NELF release from immediate early genesPromoter RNA links transcriptional regulation of inflammatory pathway genes.Tumor cell-targeted delivery of nanoconjugated oligonucleotides in composite spheroidsLentivirus-mediated knockdown of eukaryotic translation initiation factor 3 subunit D inhibits proliferation of HCT116 colon cancer cellsReversing multidrug resistance in Caco-2 by silencing MDR1, MRP1, MRP2, and BCL-2/BCL-xL using liposomal antisense oligonucleotides.High-throughput screening identifies small molecules that enhance the pharmacological effects of oligonucleotides.Long noncoding RNAs in development and cancer: potential biomarkers and therapeutic targets.Targeting Highly Structured RNA by Cooperative Action of siRNAs and Helper Antisense Oligomers in Living CellsHematologic malignancies: newer strategies to counter the BCL-2 protein.Retro-1 Analogues Differentially Affect Oligonucleotide Delivery and Toxin Trafficking.Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression.Targeted p21WAF1/CIP1 activation by RNAa inhibits hepatocellular carcinoma cells.Allele-selective inhibition of trinucleotide repeat genes.Engineering Duplex RNAs for Challenging Targets: Recognition of GGGGCC/CCCCGG Repeats at the ALS/FTD C9orf72 LocusUse of short interfering RNA delivered by cationic liposomes to enable efficient down-regulation of PTPN22 gene in human T lymphocytesMechanism of allele-selective inhibition of huntingtin expression by duplex RNAs that target CAG repeats: function through the RNAi pathwayThe small molecule Retro-1 enhances the pharmacological actions of antisense and splice switching oligonucleotides.Modulation of hepcidin to treat iron deregulation: potential clinical applications.Argonaute 2-dependent Regulation of Gene Expression by Single-stranded miRNA MimicsThe delivery of therapeutic oligonucleotidesRNA duplexes with abasic substitutions are potent and allele-selective inhibitors of huntingtin and ataxin-3 expression.ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy.Invaders: Recognition of Double-Stranded DNA by Using Duplexes Modified with Interstrand Zippers of 2'-O-(Pyren-1-yl)methyl-ribonucleotidesAllele-selective inhibition of expression of huntingtin and ataxin-3 by RNA duplexes containing unlocked nucleic acid substitutions.Transcriptional silencing by single-stranded RNAs targeting a noncoding RNA that overlaps a gene promoter.Synthesis and characterization of oligodeoxyribonucleotides modified with 2'-amino-α-L-LNA adenine monomers: high-affinity targeting of single-stranded DNASite-specific antibody-polymer conjugates for siRNA delivery.Enhanced splice correction by 3', 5'-serinol and 2'-(ω-O-methylserinol) guarded OMe-RNA/DNA mixmers in cells
P2860
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P2860
Silencing disease genes in the laboratory and the clinic
description
2011 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2011
@ast
im November 2011 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 9 November 2011)
@en
wetenschappelijk artikel (gepubliceerd op 2011/11/09)
@nl
наукова стаття, опублікована в листопаді 2011
@uk
مقالة علمية (نشرت في 9-11-2011)
@ar
name
Silencing disease genes in the laboratory and the clinic
@ast
Silencing disease genes in the laboratory and the clinic
@en
type
label
Silencing disease genes in the laboratory and the clinic
@ast
Silencing disease genes in the laboratory and the clinic
@en
prefLabel
Silencing disease genes in the laboratory and the clinic
@ast
Silencing disease genes in the laboratory and the clinic
@en
P2860
P3181
P356
P1476
Silencing disease genes in the laboratory and the clinic
@en
P2093
David R Corey
P2860
P304
P3181
P356
10.1002/PATH.2993
P577
2011-11-09T00:00:00Z