Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions
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Hypergravity exposure during gestation modifies the TCRβ repertoire of newborn miceAn autoregulatory mechanism imposes allosteric control on the V(D)J recombinase by histone H3 methylation.Localized DNA demethylation at recombination intermediates during immunoglobulin heavy chain gene assembly.Insertion of an imprinted insulator into the IgH locus reveals developmentally regulated, transcription-dependent control of V(D)J recombination.RAG1-mediated ubiquitylation of histone H3 is required for chromosomal V(D)J recombination.Cooperative recruitment of HMGB1 during V(D)J recombination through interactions with RAG1 and DNA.Individual heritable differences result in unique cell lymphocyte receptor repertoires of naïve and antigen-experienced cells.H3K4me3 induces allosteric conformational changes in the DNA-binding and catalytic regions of the V(D)J recombinaseEpigenetic aspects of lymphocyte antigen receptor gene rearrangement or 'when stochasticity completes randomness'.The epigenetic landscape of B lymphocyte tolerance to self.Modeling of the RAG reaction mechanism.Transcription-coupled eviction of histones H2A/H2B governs V(D)J recombination.Epigenetic modifications of the VH region after DJH recombination in Pro-B cells.Sequential Enhancer Sequestration Dysregulates Recombination Center Formation at the IgH Locus.
P2860
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P2860
Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Localized epigenetic changes i ...... s recombinase to DJH junctions
@en
type
label
Localized epigenetic changes i ...... s recombinase to DJH junctions
@en
prefLabel
Localized epigenetic changes i ...... s recombinase to DJH junctions
@en
P2093
P2860
P356
P1433
P1476
Localized epigenetic changes i ...... s recombinase to DJH junctions
@en
P2093
David G Schatz
Frederick W Alt
Irina Ivanova
Ramesh Subrahmanyam
Ranjan Sen
Tirtha Chakraborty
Yanhong Ji
P2860
P304
P356
10.1038/NI.2447
P407
P577
2012-10-28T00:00:00Z