Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray. - Wikidata - wikimedia - TriplyDB

Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray.

Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray.

http://www.wikidata.org/entity/Q36938417

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Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception Arachidonic acid cytochrome P450 epoxygenase pathway Advances in Our Understanding of Oxylipins Derived from Dietary PUFAs Cytochrome P450 epoxygenase pathway of polyunsaturated fatty acid metabolism The role of long chain fatty acids and their epoxide metabolites in nociceptive signaling Stabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancer Targeting epoxides for organ damage in hypertension The 2014 Bernard B. Brodie award lecture-epoxide hydrolases: drug metabolism to therapeutics for chronic pain Epoxyeicosanoid signaling in CNS function and disease Omeprazole increases the efficacy of a soluble epoxide hydrolase inhibitor in a PGE₂ induced pain model Cytochrome P450 eicosanoids and cerebral vascular function Deficits in neuronal cytochrome P450 activity attenuate opioid analgesia but not opioid side effects.Significance of neuronal cytochrome P450 activity in opioid-mediated stress-induced analgesia.Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts.Cytochrome P450 2C24: Expression, Tissue Distribution, High-Throughput Assay, and Pharmacological Inhibition.Soluble epoxide hydrolase inhibition is antinociceptive in a mouse model of diabetic neuropathy.The role of epoxide hydrolases in health and disease.Temporal changes of cytochrome P450 (Cyp) and eicosanoid-related gene expression in the rat brain after traumatic brain injury.Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP.Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic.20-Iodo-14,15-epoxyeicosa-8(Z)-enoyl-3-azidophenylsulfonamide: photoaffinity labeling of a 14,15-epoxyeicosatrienoic acid receptor Opioid receptors and cardioprotection - 'opioidergic conditioning' of the heart Neuronal cytochrome P450 activity and opioid analgesia: relevant sites and mechanisms.Opioid Analgesia in P450 Gene Cluster Knockout Mice: A Search for Analgesia-Relevant Isoforms Soluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways.Genetic enhancement of microsomal epoxide hydrolase improves metabolic detoxification but impairs cerebral blood flow regulation.20-125Iodo-14,15-epoxyeicosa-5(Z)-enoic acid: a high-affinity radioligand used to characterize the epoxyeicosatrienoic acid antagonist binding site.Pressure-induced myogenic tone and role of 20-HETE in mediating autoregulation of cerebral blood flow.Morphinan alkaloids labeled with tritium: synthesis and applications.Soluble epoxide hydrolase activity and pharmacologic inhibition in horses with chronic severe laminitis.Characterization of transgenic mice with neuron-specific expression of soluble epoxide hydrolase.Epoxygenated fatty acids and soluble epoxide hydrolase inhibition: novel mediators of pain reduction.14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) surrogates: carboxylate modifications.Soluble Epoxide Hydrolase Inhibitor and 14,15-Epoxyeicosatrienoic Acid-Facilitated Long-Term Potentiation through cAMP and CaMKII in the Hippocampus.Endometriosis Is Associated With a Shift in MU Opioid and NMDA Receptor Expression in the Brain Periaqueductal Gray.The soluble epoxide hydrolase as a pharmaceutical target for pain management.Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia.

P2860

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P2860

Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray.

http://www.wikidata.org/entity/Q36938417

description

2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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Antinociception produced by 14 ...... rolateral periaqueductal gray.

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Antinociception produced by 14 ...... rolateral periaqueductal gray.

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Journal of Pharmacology and Experimental Therapeutics

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Antinociception produced by 14 ...... trolateral periaqueductal gray

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P2093

David R Harder

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Hsiang-En Wu

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Jayashree Narayanan

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Leon F Tseng

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Lucas M Hart

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Maia Terashvili

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Phillip F Pratt

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P2860

Epoxyeicosatrienoic acids (EETs): metabolism and biochemical function

Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants

Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.

Inhibition of soluble epoxide hydrolase reduces LPS-induced thermal hyperalgesia and mechanical allodynia in a rat model of inflammatory pain

Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes

Soluble epoxide hydrolase is a therapeutic target for acute inflammation

Molecular cloning, enzymatic characterization, developmental expression, and cellular localization of a mouse cytochrome P450 highly expressed in kidney.

Breast tumor aromatase: functional role and transcriptional regulation.

Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain.

Evidence for epsilon-opioid receptor-mediated beta-endorphin-induced analgesia.

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614-622

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326

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5357373

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18492947

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