Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray.
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Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseasesImpact of soluble epoxide hydrolase and epoxyeicosanoids on human healthSoluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociceptionArachidonic acid cytochrome P450 epoxygenase pathwayAdvances in Our Understanding of Oxylipins Derived from Dietary PUFAsCytochrome P450 epoxygenase pathway of polyunsaturated fatty acid metabolismThe role of long chain fatty acids and their epoxide metabolites in nociceptive signalingStabilized epoxygenated fatty acids regulate inflammation, pain, angiogenesis and cancerTargeting epoxides for organ damage in hypertensionThe 2014 Bernard B. Brodie award lecture-epoxide hydrolases: drug metabolism to therapeutics for chronic painEpoxyeicosanoid signaling in CNS function and diseaseOmeprazole increases the efficacy of a soluble epoxide hydrolase inhibitor in a PGE₂ induced pain modelCytochrome P450 eicosanoids and cerebral vascular functionDeficits in neuronal cytochrome P450 activity attenuate opioid analgesia but not opioid side effects.Significance of neuronal cytochrome P450 activity in opioid-mediated stress-induced analgesia.Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signalingEvidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts.Cytochrome P450 2C24: Expression, Tissue Distribution, High-Throughput Assay, and Pharmacological Inhibition.Soluble epoxide hydrolase inhibition is antinociceptive in a mouse model of diabetic neuropathy.The role of epoxide hydrolases in health and disease.Temporal changes of cytochrome P450 (Cyp) and eicosanoid-related gene expression in the rat brain after traumatic brain injury.Analgesia mediated by soluble epoxide hydrolase inhibitors is dependent on cAMP.Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic.20-Iodo-14,15-epoxyeicosa-8(Z)-enoyl-3-azidophenylsulfonamide: photoaffinity labeling of a 14,15-epoxyeicosatrienoic acid receptorOpioid receptors and cardioprotection - 'opioidergic conditioning' of the heartNeuronal cytochrome P450 activity and opioid analgesia: relevant sites and mechanisms.Opioid Analgesia in P450 Gene Cluster Knockout Mice: A Search for Analgesia-Relevant IsoformsSoluble epoxide hydrolase and epoxyeicosatrienoic acids modulate two distinct analgesic pathways.Genetic enhancement of microsomal epoxide hydrolase improves metabolic detoxification but impairs cerebral blood flow regulation.20-125Iodo-14,15-epoxyeicosa-5(Z)-enoic acid: a high-affinity radioligand used to characterize the epoxyeicosatrienoic acid antagonist binding site.Pressure-induced myogenic tone and role of 20-HETE in mediating autoregulation of cerebral blood flow.Morphinan alkaloids labeled with tritium: synthesis and applications.Soluble epoxide hydrolase activity and pharmacologic inhibition in horses with chronic severe laminitis.Characterization of transgenic mice with neuron-specific expression of soluble epoxide hydrolase.Epoxygenated fatty acids and soluble epoxide hydrolase inhibition: novel mediators of pain reduction.14,15-Epoxyeicosa-5,8,11-trienoic Acid (14,15-EET) surrogates: carboxylate modifications.Soluble Epoxide Hydrolase Inhibitor and 14,15-Epoxyeicosatrienoic Acid-Facilitated Long-Term Potentiation through cAMP and CaMKII in the Hippocampus.Endometriosis Is Associated With a Shift in MU Opioid and NMDA Receptor Expression in the Brain Periaqueductal Gray.The soluble epoxide hydrolase as a pharmaceutical target for pain management.Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia.
P2860
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P2860
Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Antinociception produced by 14 ...... rolateral periaqueductal gray.
@en
type
label
Antinociception produced by 14 ...... rolateral periaqueductal gray.
@en
prefLabel
Antinociception produced by 14 ...... rolateral periaqueductal gray.
@en
P2093
P2860
P356
P1476
Antinociception produced by 14 ...... trolateral periaqueductal gray
@en
P2093
David R Harder
Hsiang-En Wu
Jayashree Narayanan
Leon F Tseng
Lucas M Hart
Maia Terashvili
Phillip F Pratt
P2860
P304
P356
10.1124/JPET.108.136739
P407
P577
2008-05-20T00:00:00Z