Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes
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A mitochondrial pathway for biosynthesis of lipid mediatorsP450 subfamily CYP2J and their role in the bioactivation of arachidonic acid in extrahepatic tissuesCYP2U1, a novel human thymus- and brain-specific cytochrome P450, catalyzes omega- and (omega-1)-hydroxylation of fatty acidsInterethnic and intraethnic variability of CYP2C8 and CYP2C9 polymorphisms in healthy individuals11,12-EET increases porto-sinusoidal resistance and may play a role in endothelial dysfunction of portal hypertensionAnti-inflammatory effects of epoxyeicosatrienoic acidsCYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET)Sex- and isoform-specific mechanism of neuroprotection by transgenic expression of P450 epoxygenase in vascular endotheliumOntogenesis of CYP2C-dependent arachidonic acid metabolism in the human liver: relationship with sudden infant death syndrome.Summary of information on human CYP enzymes: human P450 metabolism data.PPARalpha-mediated effects of dietary lipids on intestinal barrier gene expression.Are cytochrome P450 CYP2C8 and CYP2C9 polymorphisms associated with ibuprofen response in very preterm infants?The role of CYP2B6 in human xenobiotic metabolism.Mitochondrial P450-dependent arachidonic acid metabolism by TCDD-induced hepatic CYP1A5; conversion of EETs to DHETs by mitochondrial soluble epoxide hydrolase.Regulation of cytochrome P450 (CYP) genes by nuclear receptors.Liver-specific cytochrome P450 CYP2C22 is a direct target of retinoic acid and a retinoic acid-metabolizing enzyme in rat liver.Renal drug metabolism in humans: the potential for drug-endobiotic interactions involving cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT).Cytochrome P450 2J2: distribution, function, regulation, genetic polymorphisms and clinical significance.Multiple cytochrome P-450 genes are concomitantly regulated by vitamin A under steady-state conditions and by retinoic acid during hepatic first-pass metabolism.Temporal changes of cytochrome P450 (Cyp) and eicosanoid-related gene expression in the rat brain after traumatic brain injury.Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lung.Drug-metabolizing cytochrome P450s in the brain.Effects of acetylenic epoxygenase inhibitors on recombinant cytochrome p450sPharmacogenetics of drug-metabolizing enzymes in US Hispanics.Xenobiotic-metabolizing cytochromes P450 in ontogeny: evolving perspective.The xenobiotic inhibitor profile of cytochrome P4502C8.Cytochrome P450-type hydroxylation and epoxidation in a tyrosine-liganded hemoprotein, catalase-related allene oxide synthase.Inhibition of carcinoma cell motility by epoxyeicosatrienoic acid (EET) antagonists.Functional characterization of zebrafish cytochrome P450 1 family proteins expressed in yeastCYP1A in TCDD toxicity and in physiology-with particular reference to CYP dependent arachidonic acid metabolism and other endogenous substrates.Functional Characterization of Human CYP2C9 Allelic Variants in COS-7 Cells.Antinociception produced by 14,15-epoxyeicosatrienoic acid is mediated by the activation of beta-endorphin and met-enkephalin in the rat ventrolateral periaqueductal gray.Roles of the epoxygenase CYP2J2 in the endothelium.Inhibition of Human Cytochrome P450 2c8-catalyzed Amodiaquine N-desethylation: Effect of Five Traditionally and Commonly Used Herbs.Endogenous functions of the aryl hydrocarbon receptor (AHR): intersection of cytochrome P450 1 (CYP1)-metabolized eicosanoids and AHR biology.Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease.Increases in levels of epoxyeicosatrienoic and dihydroxyeicosatrienoic acids (EETs and DHETs) in liver and heart in vivo by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and in hepatic EET:DHET ratios by cotreatment with TCDD and the soluble epoxide hyQSAR of cytochrome inhibitors.Roles of Eicosanoids in Prostate Cancer.The role of hepatic cytochrome P-450 in sepsis.
P2860
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P2860
Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver microsomes
description
1995 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1995
@ast
im Juli 1995 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1995/07/10)
@sk
vědecký článek publikovaný v roce 1995
@cs
wetenschappelijk artikel (gepubliceerd op 1995/07/10)
@nl
наукова стаття, опублікована в липні 1995
@uk
مقالة علمية (نشرت في 10-7-1995)
@ar
name
Arachidonic acid metabolism by ...... tion in human liver microsomes
@ast
Arachidonic acid metabolism by ...... tion in human liver microsomes
@en
Arachidonic acid metabolism by ...... tion in human liver microsomes
@nl
type
label
Arachidonic acid metabolism by ...... tion in human liver microsomes
@ast
Arachidonic acid metabolism by ...... tion in human liver microsomes
@en
Arachidonic acid metabolism by ...... tion in human liver microsomes
@nl
prefLabel
Arachidonic acid metabolism by ...... tion in human liver microsomes
@ast
Arachidonic acid metabolism by ...... tion in human liver microsomes
@en
Arachidonic acid metabolism by ...... tion in human liver microsomes
@nl
P2093
P3181
P1476
Arachidonic acid metabolism by ...... tion in human liver microsomes
@en
P2093
A. B. Rifkind
D. J. Waxman
T. K. Chang
P304
P3181
P356
10.1016/0003-9861(95)90023-3
P407
P577
1995-07-10T00:00:00Z