Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.
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Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens.Microbial antigen mimics activate diabetogenic CD8 T cells in NOD mice.Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies.Lipopeptides: a novel antigen repertoire presented by major histocompatibility complex class I molecules.The Role of the Intestinal Microbiome in Type 1 Diabetes Pathogenesis.Tumor-targeting domains for chimeric antigen receptor T cells.Thermal Stability of Heterotrimeric pMHC Proteins as Determined by Circular Dichroism Spectroscopy.How an alloreactive T-cell receptor achieves peptide and MHC specificity.Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4+ T Cells in Peripheral Blood of Subjects with Type 1 Diabetes.Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.Disease etiology and diagnosis by TCR repertoire analysis goes viral.A "hotspot" for autoimmune T cells in type 1 diabetes.Implications of the diversity of class I HLA associations in psoriatic arthritis.NFM Cross-Reactivity to MOG Does Not Expand a Critical Threshold Level of High-Affinity T Cells Necessary for Onset of Demyelinating Disease.Dual Molecular Mechanisms Govern Escape at Immunodominant HLA A2-Restricted HIV Epitope.A study of CDR3 loop dynamics reveals distinct mechanisms of peptide recognition by T-cell receptors exhibiting different levels of cross-reactivity.Emerging Concepts in TCR Specificity: Rationalizing and (Maybe) Predicting Outcomes.Autoreactive T cells in type 1 diabetes.CRISPR-mediated TCR replacement generates superior anticancer transgenic T cells.Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors.In Silico and Structural Analyses Demonstrate That Intrinsic Protein Motions Guide T Cell Receptor Complementarity Determining Region Loop Flexibility.Peptide-MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations.HLA variation and disease.
P2860
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P2860
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Hotspot autoimmune T cell rece ...... ulin peptide cross-reactivity.
@en
type
label
Hotspot autoimmune T cell rece ...... ulin peptide cross-reactivity.
@en
prefLabel
Hotspot autoimmune T cell rece ...... ulin peptide cross-reactivity.
@en
P2093
P2860
P50
P356
P1476
Hotspot autoimmune T cell rece ...... ulin peptide cross-reactivity.
@en
P2093
Andrea J Schauenberg
Andrew Trimby
Ania Skowera
Anna Fuller
Anna M Bulek
Barbara Szomolay
Garry Dolton
Linda Wooldridge
Pierre J Rizkallah
Prithiviraj Jothikumar
P2860
P304
P356
10.1172/JCI85679
P407
P577
2016-05-16T00:00:00Z