about
Phase I trial of a CD8+ T-cell peptide epitope-based vaccine for infectious mononucleosisA T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I moleculeImpact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infectionNatural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognitionGerm Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell ReceptorHard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptabilityAllelic polymorphism in the T cell receptor and its impact on immune responsesGenetic and Structural Basis for Selection of a Ubiquitous T Cell Receptor Deployed in Epstein-Barr Virus InfectionT-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen TargetingPeptide length determines the outcome of TCR/peptide-MHCI engagementStructural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.The impact of a large and frequent deletion in the human TCR β locus on antiviral immunityHighly Divergent T-cell Receptor Binding Modes Underlie Specific Recognition of a Bulged Viral Peptide bound to a Human Leukocyte Antigen Class I MoleculeT-cell Receptor Specificity Maintained by Altered ThermodynamicsImmune self-reactivity triggered by drug-modified HLA-peptide repertoireMolecular Imprint of Exposure to Naturally Occurring Genetic Variants of Human Cytomegalovirus on the T cell RepertoireA Molecular Basis for the Interplay between T Cells, Viral Mutants, and Human Leukocyte Antigen MicropolymorphismHLA peptide length preferences control CD8+ T cell responsesRecognition of vitamin B metabolites by mucosal-associated invariant T cellsAn extensive antigenic footprint underpins immunodominant TCR adaptability against a hypervariable viral determinantT Cell Cross-Reactivity between a Highly Immunogenic EBV Epitope and a Self-Peptide Naturally Presented by HLA-B*18:01+ CellsMR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usageAntibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRsCD8(+) T cell cross-reactivity profiles and HIV-1 immune escape towards an HLA-B35-restricted immunodominant Nef epitope.Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining.A single autoimmune T cell receptor recognizes more than a million different peptides.Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors.Naive CD8⁺ T-cell precursors display structured TCR repertoires and composite antigen-driven selection dynamicsβ-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure.Endogenous presentation of CD8+ T cell epitopes from Epstein-Barr virus-encoded nuclear antigen 1.The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation.Engineered T cell receptors and their potential in molecular medicine.Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.Bias in the αβ T-cell repertoire: implications for disease pathogenesis and vaccination.Structural and biophysical determinants of αβ T-cell antigen recognition.T cell antigen receptor recognition of antigen-presenting molecules.Understanding the complexity and malleability of T-cell recognition.Suppression of Metastases Using a New Lymphocyte Checkpoint Target for Cancer Immunotherapy.Coinfection with Human Cytomegalovirus Genetic Variants in Transplant Recipients and Its Impact on Antiviral T Cell Immune Reconstitution.Molecular Pathways: Targeting CD96 and TIGIT for Cancer Immunotherapy.
P50
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P50
name
John J Miles
@ast
John J Miles
@en
John J Miles
@es
John J Miles
@nl
type
label
John J Miles
@ast
John J Miles
@en
John J Miles
@es
John J Miles
@nl
prefLabel
John J Miles
@ast
John J Miles
@en
John J Miles
@es
John J Miles
@nl