Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases
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Systematic analysis of rat 12/15-lipoxygenase enzymes reveals critical role for spinal eLOX3 hepoxilin synthase activity in inflammatory hyperalgesiaSynthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenasesMechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid.A common late-stage intermediate in catalysis by 2-hydroxyethyl-phosphonate dioxygenase and methylphosphonate synthase.Parallel and competitive pathways for substrate desaturation, hydroxylation, and radical rearrangement by the non-heme diiron hydroxylase AlkB.Substrate specificity changes for human reticulocyte and epithelial 15-lipoxygenases reveal allosteric product regulation.Kinetic isotope effects in the oxidation of arachidonic acid by soybean lipoxygenase-1.Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2.Cyclooxygenase reaction mechanism of prostaglandin H synthase from deuterium kinetic isotope effects.Synthesis of Site-Specifically 13C Labeled Linoleic Acids.Lipidomics Reveals Dramatic Physiological Kinetic Isotope Effects during the Enzymatic Oxygenation of Polyunsaturated Fatty Acids Ex Vivo.Is Regioselectivity in the Enzyme-Catalyzed Hydroperoxidation of Arachidonic Acid Necessarily Determined by Hydrogen Abstraction? The Case of Rabbit Leu597Ala/Ile663Ala ALOX15 Mutant.Influence of Substrate Dideuteration on the Reaction of the Bifunctional Heme Enzyme Psi Factor Producing Oxygenase A (PpoA)
P2860
Q28284941-EE8097E1-6224-43B7-B9C4-CE86D9433BFFQ33903800-24CA550A-2B99-4691-8F63-8247789BB758Q34109730-92048500-A018-41A2-B91B-23A29BDCEF41Q35806102-A51A2BAC-73D6-4438-B032-DB9EEA746E46Q36493437-09874AF3-7B63-441D-96DF-EDFA1E39230FQ37015837-2ADAA29C-B67A-41CE-AFB7-607AF61160C4Q37120874-96BCCECE-4150-426D-92C7-6EC84100D60EQ37352678-FFC77D8F-4B78-4CC6-A6C6-1C14742E133BQ42077061-22A25541-A426-4545-8382-32720C0C9ED3Q42318821-9DD8BBE5-7FEC-432A-831A-4E236C67A0E6Q48175529-2D58C0FA-B637-46E7-AC77-4445CC5E5D9DQ48294141-E41A898F-6F93-4F40-AC81-F3FE27B70234Q57546322-B2C42B97-4DC7-4778-B8CF-12F8982D98AF
P2860
Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Isotope sensitive branching an ...... human 12- and 15-lipoxygenases
@en
type
label
Isotope sensitive branching an ...... human 12- and 15-lipoxygenases
@en
prefLabel
Isotope sensitive branching an ...... human 12- and 15-lipoxygenases
@en
P2093
P2860
P356
P1433
P1476
Isotope sensitive branching an ...... human 12- and 15-lipoxygenases
@en
P2093
Aaron T Wecksler
Chris M McGinley
Erika N Segraves
Theodore R Holman
P2860
P304
P356
10.1021/BI800308Q
P407
P577
2008-06-12T00:00:00Z