Local not systemic modulation of dendritic cell S1P receptors in lung blunts virus-specific immune responses to influenza.
about
Actions of a picomolar short-acting S1P₁ agonist in S1P₁-eGFP knock-in miceDiscovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonistsDiscovery, synthesis and SAR analysis of novel selective small molecule S1P4-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotypeModulating the Innate Immune Response to Influenza A Virus: Potential Therapeutic Use of Anti-Inflammatory DrugsRegulating the adaptive immune response to respiratory virus infectionThree phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapySphingosine 1-phosphate receptor agonists: a patent review (2010-2012)Networks of Host Factors that Interact with NS1 Protein of Influenza A VirusCombinations of L-NG-monomethyl-arginine and oseltamivir against pandemic influenza A virus infections in mice.Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus.Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection.Prophylactic administration of bacterially derived immunomodulators improves the outcome of influenza virus infection in a murine model.Animal model of respiratory syncytial virus: CD8+ T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy.Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (S1P4) receptor antagonists.Modulation of chemokines and allergic airway inflammation by selective local sphingosine-1-phosphate receptor 1 agonism in lungsDoes cytokine signaling link sphingolipid metabolism to host defense and immunity against virus infections?CD8+ T cells control Ross River virus infection in musculoskeletal tissues of infected mice.Treatment with a sphingosine analog after the inception of house dust mite-induced airway inflammation alleviates key features of experimental asthma.The transforming growth factor beta signaling pathway is critical for the formation of CD4 T follicular helper cells and isotype-switched antibody responses in the lung mucosa.SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1P₄) receptor.A ceramide analogue stimulates dendritic cells to promote T cell responses upon virus infectionsChemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic moleculesEffect of statin treatments on highly pathogenic avian influenza H5N1, seasonal and H1N1pdm09 virus infections in BALB/c miceLessons learned and concepts formed from study of the pathogenesis of the two negative-strand viruses lymphocytic choriomeningitis and influenza.Antigen-activated dendritic cells ameliorate influenza A infectionsA critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection.Innate immune control and regulation of influenza virus infections.A Phosphorylatable Sphingosine Analog Induces Airway Smooth Muscle Cytostasis and Reverses Airway Hyperresponsiveness in Experimental Asthma.Quelling the storm: utilization of sphingosine-1-phosphate receptor signaling to ameliorate influenza virus-induced cytokine storm.Cellular immune reactions in the lung.Influenza viral manipulation of sphingolipid metabolism and signaling to modulate host defense system.S1P signaling: new therapies and opportunities.Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection.Reduction of Pertussis Inflammatory Pathology by Therapeutic Treatment With Sphingosine-1-Phosphate Receptor Ligands by a Pertussis Toxin-Insensitive Mechanism.Sphingosine 1-phosphate-metabolizing enzymes control influenza virus propagation and viral cytopathogenicity.Sphingosine 1-Phosphate Lyase Enhances the Activation of IKKε To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection.A new shield for a cytokine storm.Sphingosine analogue AAL-R increases TLR7-mediated dendritic cell responses via p38 and type I IFN signaling pathways.Sphingosine analog AAL-R promotes activation of LCMV-infected dendritic cells.Sphingolipids role in the regulation of inflammatory response: From leukocyte biology to bacterial infection.
P2860
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P2860
Local not systemic modulation of dendritic cell S1P receptors in lung blunts virus-specific immune responses to influenza.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Local not systemic modulation ...... immune responses to influenza.
@en
type
label
Local not systemic modulation ...... immune responses to influenza.
@en
prefLabel
Local not systemic modulation ...... immune responses to influenza.
@en
P2093
P2860
P356
P1476
Local not systemic modulation ...... immune responses to influenza.
@en
P2093
Bumsuk Hahm
David Marsolais
Edward Roberts
Hugh Rosen
Kevin B Walsh
Kurt H Edelmann
Michael B A Oldstone
Miguel Guerrero
Yasuko Hatta
P2860
P304
P356
10.1124/MOL.108.048769
P577
2008-06-24T00:00:00Z