Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid
about
Recent applications of engineered animal antioxidant deficiency models in human nutrition and chronic diseaseBehavioral and monoamine changes following severe vitamin C deficiencyEffect of vitamin C deficiency during postnatal development on adult behavior: functional phenotype of Gulo-/- knockout mice.Hippocampal memory enhancing activity of pine needle extract against scopolamine-induced amnesia in a mouse modelAscorbic acid and the brain: rationale for the use against cognitive decline.Vitamin C deficiency increases basal exploratory activity but decreases scopolamine-induced activity in APP/PSEN1 transgenic miceChronic vitamin C deficiency promotes redox imbalance in the brain but does not alter sodium-dependent vitamin C transporter 2 expression.Vitamin C distribution and retention in the mouse brain.Low ascorbic acid and increased oxidative stress in gulo(-/-) mice during developmentLow vitamin C and increased oxidative stress and cell death in mice that lack the sodium-dependent vitamin C transporter SVCT2.Intracranial V. cholerae sialidase protects against excitotoxic neurodegenerationAbnormal vibrissa-related behavior and loss of barrel field inhibitory neurons in 5xFAD transgenics.Increased expression of SVCT2 in a new mouse model raises ascorbic acid in tissues and protects against paraquat-induced oxidative damage in lung.Does vitamin C deficiency affect cognitive development and function?A single intramuscular injection of rAAV-mediated mutant erythropoietin protects against MPTP-induced parkinsonism.Antioxidant supplementation ameliorates molecular deficits in Smith-Lemli-Opitz syndromeLow brain ascorbic acid increases susceptibility to seizures in mouse models of decreased brain ascorbic acid transport and Alzheimer's diseaseDifferential regulation of the ascorbic acid transporter SVCT2 during development and in response to ascorbic acid depletion.Vitamin C deficiency in the brain impairs cognition, increases amyloid accumulation and deposition, and oxidative stress in APP/PSEN1 and normally aging mice.Noninvasive quantification of human brain antioxidant concentrations after an intravenous bolus of vitamin C.Sodium-dependent vitamin C transporter-2 mediates vitamin C transport at the cortical nerve terminal.Vitamin C modulates the metabolic and cytokine profiles, alleviates hepatic endoplasmic reticulum stress, and increases the life span of Gulo-/- mice.Antioxidants and cognitive training interact to affect oxidative stress and memory in APP/PSEN1 mice.Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2.Vitamin C reduces spatial learning deficits in middle-aged and very old APP/PSEN1 transgenic and wild-type mice.Ascorbic acid attenuates scopolamine-induced spatial learning deficits in the water maze.Combined vitamin C and E deficiency induces motor defects in gulo(-/-)/SVCT2(+/-) mice.Effect of Intravenous High Dose Vitamin C on Postoperative Pain and Morphine Use after Laparoscopic Colectomy: A Randomized Controlled Trial.Multiple free-radical scavenging (MULTIS) capacity in cattle serum.Vitamin C activation of the biosynthesis of epoxyeicosatrienoic acids.Oxidative imbalance and anxiety disorders.Oxidative stress, serotonergic changes and decreased ultrasonic vocalizations in a mouse model of Smith-Lemli-Opitz syndrome.Stereological studies of the effects of sodium benzoate or ascorbic acid on rats` cerebellum.Endogenous anxiety and stress responses in water maze and Barnes maze spatial memory tasks.Attenuation of sepsis-induced organ injury in mice by vitamin C.Ascorbic acid prevents protein oxidation in livers of senescence marker protein-30/gluconolactonase knockout mice.Effect of vitamin C on morphine use after laparoscopic cholecystectomy: a randomized controlled trial.Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer's disease and a novel protective role for ascorbate.Feeding Vitamin C during Neonatal and Juvenile Growth Improves Learning and Memory of Rats.Targeted deletion of GD3 synthase protects against MPTP-induced neurodegeneration.
P2860
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P2860
Elevated oxidative stress and sensorimotor deficits but normal cognition in mice that cannot synthesize ascorbic acid
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Elevated oxidative stress and ...... annot synthesize ascorbic acid
@en
type
label
Elevated oxidative stress and ...... annot synthesize ascorbic acid
@en
prefLabel
Elevated oxidative stress and ...... annot synthesize ascorbic acid
@en
P2093
P2860
P1476
Elevated oxidative stress and ...... annot synthesize ascorbic acid
@en
P2093
James M May
Kristen L Van Den Bossche
Sarah S Yu
P2860
P304
P356
10.1111/J.1471-4159.2008.05469.X
P407
P577
2008-05-07T00:00:00Z