Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression. - Wikidata - wikimedia - TriplyDB

Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression.

Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression.

http://www.wikidata.org/entity/Q36959003

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Insights into granulosa cell tumors using spontaneous or genetically engineered mouse models Mammalian target of rapamycin is a therapeutic target for murine ovarian endometrioid adenocarcinomas with dysregulated Wnt/β-catenin and PTEN Deletion of Arid1a in Reproductive Tract Mesenchymal Cells Reduces Fertility in Female Mice.FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development.Proteomic profiling of a mouse model for ovarian granulosa cell tumor identifies VCP as a highly sensitive serum tumor marker in several human cancers.Decidual PTEN expression is required for trophoblast invasion in the mouse.Beta-catenin (CTNNB1) promotes preovulatory follicular development but represses LH-mediated ovulation and luteinization.Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells Dysregulation of WNT/CTNNB1 and PI3K/AKT signaling in testicular stromal cells causes granulosa cell tumor of the testis A mouse surgical model for metastatic ovarian granulosa cell tumor The ovary is an alternative site of origin for high-grade serous ovarian cancer in mice.Minireview: physiological and pathological actions of RAS in the ovary.The ovary: basic biology and clinical implications MicroRNA profiling of ovarian granulosa cell tumours reveals novel diagnostic and prognostic markers.WNT4 is required for normal ovarian follicle development and female fertility.Oncogenic role of the E3 ubiquitin ligase NEDD4-1, a PTEN negative regulator, in non-small-cell lung carcinomas.Molecular and functional characteristics of ovarian surface epithelial cells transformed by KrasG12D and loss of Pten in a mouse model in vivo.Bone morphogenetic protein signaling transcription factor (SMAD) function in granulosa cells.Combined comparative genomic hybridization and transcriptomic analyses of ovarian granulosa cell tumors point to novel candidate driver genes.Convergence of 3',5'-cyclic adenosine 5'-monophosphate/protein kinase A and glycogen synthase kinase-3beta/beta-catenin signaling in corpus luteum progesterone synthesis.Either Kras activation or Pten loss similarly enhance the dominant-stable CTNNB1-induced genetic program to promote granulosa cell tumor development in the ovary and testis.Conditional steroidogenic cell-targeted deletion of TSPO unveils a crucial role in viability and hormone-dependent steroid formation.Minireview: animal models and mechanisms of ovarian cancer development.Consequences of RAS and MAPK activation in the ovary: the good, the bad and the ugly.New insights into ovarian function.Technical challenges and limitations of current mouse models of ovarian cancer.PTEN loss and HOXA10 expression are associated with ovarian endometrioid adenocarcinoma differentiation and progression.Anti-VEGFA Therapy Reduces Tumor Growth and Extends Survival in a Murine Model of Ovarian Granulosa Cell Tumor Germ cell specific overactivation of WNT/βcatenin signalling has no effect on folliculogenesis but causes fertility defects due to abnormal foetal development The mammalian ovary from genesis to revelation.Ovarian cancer mouse models: a summary of current models and their limitations.Wnt-beta-catenin pathway signals metastasis-associated tumor cell phenotypes in triple negative breast cancers.Dissecting the PI3K Signaling Axis in Pediatric Solid Tumors: Novel Targets for Clinical Integration.Pyruvate kinase, muscle isoform 2 promotes proliferation and insulin secretion of pancreatic β-cells via activating Wnt/CTNNB1 signaling.Genetics and genomics of ovarian sex cord-stromal tumors.Alterations in Wnt-β-catenin and Pten signalling play distinct roles in endometrial cancer initiation and progression.The molecular mechanism of ovarian granulosa cell tumors.Global or Granulosa Cell-Specific Pten Mutations in Combination with Elevated FSH Levels Fail to Cause Ovarian Tumours in Mice.Chronic restraint stress induces excessive activation of primordial follicles in mice ovaries.MicroRNA-10a promotes granulosa cells tumor development via PTEN-AKT/Wnt regulatory axis

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Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression.

http://www.wikidata.org/entity/Q36959003

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Synergistic effects of Pten lo ...... r development and progression.

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Derek Boerboom

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Heng-Yu Fan

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Joanne S Richards

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Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Stabilization of beta-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth

Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades

PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer

A mutation in the follicle-stimulating hormone receptor occurs frequently in human ovarian sex cord tumors

Requirement of Bmpr1a for Müllerian duct regression during male sexual development

Female development in mammals is regulated by Wnt-4 signalling

Insulin and wnt1 pathways cooperate to induce reserve cell activation in differentiation and myotube hypertrophy

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

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