The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts.
about
Eukaryotic translation initiation factor 4E is a cellular target for toxicity and death due to exposure to cadmium chlorideThe proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growthDAP-5, a novel homolog of eukaryotic translation initiation factor 4G isolated as a putative modulator of gamma interferon-induced programmed cell deathThe translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteinsIdentification of the human prostatic carcinoma oncogene PTI-1 by rapid expression cloning and differential RNA displayRepression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4EMolecular characterization of the mouse ribosomal protein S24 multigene family: a uniquely expressed intron-containing gene with cell-specific expression of three alternatively spliced mRNAsInteraction between a poly(A)-specific ribonuclease and the 5' cap influences mRNA deadenylation rates in vitroAmplification of EIF3S3 gene is associated with advanced stage in prostate cancerExpression of constitutively active 4EBP-1 enhances p27Kip1 expression and inhibits proliferation of MCF7 breast cancer cellsMisregulation of the proline rich homeodomain (PRH/HHEX) protein in cancer cells and its consequences for tumour growth and invasionSignalling to eIF4E in cancerRole of AKT/mTORC1 pathway in pancreatic β-cell proliferationOverexpression of EIF3S3 promotes cancer cell growtheIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3'UTRThe serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARalpha and regulates differentiation of hematopoietic cellsEukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levelsAn isoform of eIF4E is a component of germ granules and is required for spermatogenesis in C. elegansTranslation initiation factor eIF-4A1 mRNA is consistently overexpressed in human melanoma cellsin vitroEpigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferationEukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels.New frontiers in translational control of the cancer genomeInhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approachmRNAs containing extensive secondary structure in their 5' non-coding region translate efficiently in cells overexpressing initiation factor eIF-4ESuppression of cellular transformation by poly (A) binding protein interacting protein 2 (Paip2).4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin.Post-transcriptional RNA regulons affecting cell cycle and proliferation.Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth.Assignment of the human gene encoding eukaryotic initiation factor 4E (EIF4E) to the region q21-25 on chromosome 4.Translational regulation in cell stress and apoptosis. Roles of the eIF4E binding proteins.The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survivalAberrant eukaryotic translation initiation factor 4E-dependent mRNA transport impedes hematopoietic differentiation and contributes to leukemogenesis.PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axisInsights into 4E-BP1 and p53 mediated regulation of accelerated cell senescenceThe translation factor eIF6 is a Notch-dependent regulator of cell migration and invasionAmplification and overexpression of p40 subunit of eukaryotic translation initiation factor 3 in breast and prostate cancer.Cellular aging is a critical determinant of primary cell resistance to v-src transformation.Antisense inhibition of the PTI-1 oncogene reverses cancer phenotypes.Eukaryotic Translation Initiation Factor 4E Is a Feed-Forward Translational Coactivator of Transforming Growth Factor β Early Protransforming Events in Breast Epithelial Cells.Isolation and sequence of a cDNA encoding the cap binding protein of wheat eukaryotic protein synthesis initiation factor 4F
P2860
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P2860
The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
1992年论文
@zh
1992年论文
@zh-cn
name
The mRNA 5' cap-binding protei ...... of primary rodent fibroblasts.
@en
type
label
The mRNA 5' cap-binding protei ...... of primary rodent fibroblasts.
@en
prefLabel
The mRNA 5' cap-binding protei ...... of primary rodent fibroblasts.
@en
P2860
P356
P1476
The mRNA 5' cap-binding protei ...... of primary rodent fibroblasts.
@en
P2093
Lazaris-Karatzas A
Sonenberg N
P2860
P304
P356
10.1128/MCB.12.3.1234
P407
P577
1992-03-01T00:00:00Z