Selection of a trioxaquine as an antimalarial drug candidate. - Wikidata - wikimedia - TriplyDB

Selection of a trioxaquine as an antimalarial drug candidate.

Selection of a trioxaquine as an antimalarial drug candidate.

http://www.wikidata.org/entity/Q36965586

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The therapeutic potential of metal-based antimalarial agents: implications for the mechanism of action Ferrocene-based antimalarials Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes Antischistosomal activity of trioxaquines: in vivo efficacy and mechanism of action on Schistosoma mansoni Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities Efficacy and safety evaluation of a novel trioxaquine in the management of cerebral malaria in a mouse model.Expanding the Antimalarial Drug Arsenal-Now, But How?Hybrid compounds: from simple combinations to nanomachines.The concept of privileged structures in rational drug design: focus on acridine and quinoline scaffolds in neurodegenerative and protozoan diseases.Schistosomiasis chemotherapy.A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.The global pipeline of new medicines for the control and elimination of malaria Potent in vivo anti-malarial activity and representative snapshot pharmacokinetic evaluation of artemisinin-quinoline hybrids.The global portfolio of new antimalarial medicines under development.Malaria and iron: history and review.SC83288 is a clinical development candidate for the treatment of severe malaria.Introducing New Antimalarial Analogues of Chloroquine and Amodiaquine: A Narrative Review.Next-Generation Antimalarial Drugs: Hybrid Molecules as a New Strategy in Drug Design.Structural modifications of quinoline-based antimalarial agents: Recent developments.Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics.Microbial transformation of azaarenes and potential uses in pharmaceutical synthesis.Targeting the redox metabolism of Plasmodium falciparum.Synthesis of five- and six-membered cyclic organic peroxides: Key transformations into peroxide ring-retaining products.Recent advances in novel heterocyclic scaffolds for the treatment of drug-resistant malaria.Design and synthesis of analogues of natural products.Are Antimalarial Hybrid Molecules a Close Reality or a Distant Dream?Synthesis and Antiplasmodial Activity of Novel Chloroquine Analogues with Bulky Basic Side Chains.An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites.New medicines for malaria.In vitro activities of trioxaquines against Schistosoma mansoni.Trioxaquine PA1259 alkylates heme in the blood-feeding parasite Schistosoma mansoni Humanized mouse models infected with human Plasmodium species for antimalarial drug discovery.Computer-Aided Drug Discovery from Marine Compounds: Identification of the Three-Dimensional Structural Features Responsible for Antimalarial Activity.Blocking Plasmodium falciparum Malaria Transmission with Drugs: The Gametocytocidal and Sporontocidal Properties of Current and Prospective Antimalarials.Endoperoxide-based compounds: cross-resistance with artemisinins and selection of a Plasmodium falciparum lineage with a K13 non-synonymous polymorphism.Antimalarial mannoxanes: hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action.Profiling of the anti-malarial drug candidate SC83288 against artemisinins in Plasmodium falciparum.Drug Repurposing for Schistosomiasis: Combinations of Drugs or Biomolecules.Peroxide bond strength of antimalarial drugs containing an endoperoxide cycle. Relation with biological activity.Design, Synthesis and Evaluation of Bifunctional Acridinine-Naphthalenediimide Redox-Active Conjugates as Antimalarials

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P2860

Selection of a trioxaquine as an antimalarial drug candidate.

http://www.wikidata.org/entity/Q36965586

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2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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2008年论文

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name

Selection of a trioxaquine as an antimalarial drug candidate.

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Selection of a trioxaquine as an antimalarial drug candidate.

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Selection of a trioxaquine as an antimalarial drug candidate.

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Proceedings of the National Academy of Sciences of the United States of America

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Selection of a trioxaquine as an antimalarial drug candidate.

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Alain Pellet

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Alicia Moreno

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Dominique Mazier

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François Guillou

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Frédéric Coslédan

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Jean-Pierre Maffrand

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Laurent Fraisse

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P2860

Identification of an antimalarial synthetic trioxolane drug development candidate

Artemisinins target the SERCA of Plasmodium falciparum

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique

The antimalarial drug artemisinin alkylates heme in infected mice.

Possible modes of action of the artemisinin-type compounds.

A medicinal chemistry perspective on artemisinin and related endoperoxides.

hERG potassium channels and cardiac arrhythmia.

From mechanistic studies on artemisinin derivatives to new modular antimalarial drugs.

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105

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Bernard Meunier

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Benjamin Mordmüller

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2008-11-05T00:00:00Z

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