SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival.
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Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapiesUpdate in lung cancer and mesothelioma 2012Is cancer a metabolic disease?Novel therapeutic targets of tumor metabolismGlutamine and cancer: cell biology, physiology, and clinical opportunitiesSLC transporters as therapeutic targets: emerging opportunitiesLigand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual ScreeningTargeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour developmentAcyl-coenzyme A-binding protein regulates Beta-oxidation required for growth and survival of non-small cell lung cancer.Analysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinoma.ASCT2 (SLC1A5)-Deficient Mice Have Normal B-Cell Development, Proliferation, and Antibody Production.Generalized portrait of cancer metabolic pathways inferred from a list of genes overexpressed in cancerUpregulated SLC1A5 promotes cell growth and survival in colorectal cancerGolgi N-glycan branching N-acetylglucosaminyltransferases I, V and VI promote nutrient uptake and metabolism.2-Substituted Nγ-glutamylanilides as novel probes of ASCT2 with improved potency.2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport.GLUT1 and ASCT2 as Predictors for Prognosis of Hepatocellular CarcinomaTargeting SLC1a5-mediated glutamine dependence in non-small cell lung cancer.Preclinical Evaluation of 4-[18F]Fluoroglutamine PET to Assess ASCT2 Expression in Lung CancerHigh expression of Solute Carrier Family 1, member 5 (SLC1A5) is associated with poor prognosis in clear-cell renal cell carcinomaRole and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer.ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer.Integrative genomics analysis identifies candidate drivers at 3q26-29 amplicon in squamous cell carcinoma of the lungGlutamine activates STAT3 to control cancer cell proliferation independently of glutamine metabolism.Treatment with an SLC12A1 antagonist inhibits tumorigenesis in a subset of hepatocellular carcinomas.Altered glutamine metabolism and therapeutic opportunities for lung cancer.Therapeutic strategies impacting cancer cell glutamine metabolism.Membrane transporters for the special amino acid glutamine: structure/function relationships and relevance to human health.Tumor circulating DNA profiling in xenografted mice exposed to intermittent hypoxia.Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression.Glutaminolysis as a target for cancer therapy.ASCT2 regulates glutamine uptake and cell growth in endometrial carcinomaDrug-induced amino acid deprivation as strategy for cancer therapy.Glutamine at focus: versatile roles in cancer.Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells.ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis.1,25-Dihydroxyvitamin D inhibits glutamine metabolism in Harvey-ras transformed MCF10A human breast epithelial cell.Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions.The glutamine-alpha-ketoglutarate (AKG) metabolism and its nutritional implications.System A amino acid transporters regulate glutamine uptake and attenuate antibody-mediated arthritis.
P2860
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P2860
SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival.
@en
type
label
SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival.
@en
prefLabel
SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival.
@en
P2093
P2860
P1476
SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival.
@en
P2093
Bradford K Harris
Heidi Chen
Jonathan E Clark
Masakazu Shiota
Megan D Hoeksema
Mohamed Hassanein
Pierre P Massion
Rosana Eisenberg
William E Alborn
P2860
P304
P356
10.1158/1078-0432.CCR-12-2334
P407
P577
2012-12-04T00:00:00Z