SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival. - Wikidata - wikimedia - TriplyDB

SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival.

SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival.

http://www.wikidata.org/entity/Q36968924

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Regulation of glutamine carrier proteins by RNF5 determines breast cancer response to ER stress-inducing chemotherapies Update in lung cancer and mesothelioma 2012 Is cancer a metabolic disease?Novel therapeutic targets of tumor metabolism Glutamine and cancer: cell biology, physiology, and clinical opportunities SLC transporters as therapeutic targets: emerging opportunities Ligand Discovery for the Alanine-Serine-Cysteine Transporter (ASCT2, SLC1A5) from Homology Modeling and Virtual Screening Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development Acyl-coenzyme A-binding protein regulates Beta-oxidation required for growth and survival of non-small cell lung cancer.Analysis and interpretation of transcriptomic data obtained from extended Warburg effect genes in patients with clear cell renal cell carcinoma.ASCT2 (SLC1A5)-Deficient Mice Have Normal B-Cell Development, Proliferation, and Antibody Production.Generalized portrait of cancer metabolic pathways inferred from a list of genes overexpressed in cancer Upregulated SLC1A5 promotes cell growth and survival in colorectal cancer Golgi N-glycan branching N-acetylglucosaminyltransferases I, V and VI promote nutrient uptake and metabolism.2-Substituted Nγ-glutamylanilides as novel probes of ASCT2 with improved potency.2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport.GLUT1 and ASCT2 as Predictors for Prognosis of Hepatocellular Carcinoma Targeting SLC1a5-mediated glutamine dependence in non-small cell lung cancer.Preclinical Evaluation of 4-[18F]Fluoroglutamine PET to Assess ASCT2 Expression in Lung Cancer High expression of Solute Carrier Family 1, member 5 (SLC1A5) is associated with poor prognosis in clear-cell renal cell carcinoma Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer.ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer.Integrative genomics analysis identifies candidate drivers at 3q26-29 amplicon in squamous cell carcinoma of the lung Glutamine activates STAT3 to control cancer cell proliferation independently of glutamine metabolism.Treatment with an SLC12A1 antagonist inhibits tumorigenesis in a subset of hepatocellular carcinomas.Altered glutamine metabolism and therapeutic opportunities for lung cancer.Therapeutic strategies impacting cancer cell glutamine metabolism.Membrane transporters for the special amino acid glutamine: structure/function relationships and relevance to human health.Tumor circulating DNA profiling in xenografted mice exposed to intermittent hypoxia.Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression.Glutaminolysis as a target for cancer therapy.ASCT2 regulates glutamine uptake and cell growth in endometrial carcinoma Drug-induced amino acid deprivation as strategy for cancer therapy.Glutamine at focus: versatile roles in cancer.Nutritional Stress Induced by Tryptophan-Degrading Enzymes Results in ATF4-Dependent Reprogramming of the Amino Acid Transporter Profile in Tumor Cells.ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis.1,25-Dihydroxyvitamin D inhibits glutamine metabolism in Harvey-ras transformed MCF10A human breast epithelial cell.Targeting Cancer Metabolism: Dietary and Pharmacologic Interventions.The glutamine-alpha-ketoglutarate (AKG) metabolism and its nutritional implications.System A amino acid transporters regulate glutamine uptake and attenuate antibody-mediated arthritis.

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SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival.

http://www.wikidata.org/entity/Q36968924

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2012 nî lūn-bûn

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name

SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival.

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SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival.

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SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival.

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1078-0432.CCR-12-2334

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Clinical Cancer Research

P1476

SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival.

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P2093

Bradford K Harris

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Heidi Chen

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Jonathan E Clark

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Jun Qian

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Masakazu Shiota

http://www.w3.org/2001/XMLSchema#string

Megan D Hoeksema

http://www.w3.org/2001/XMLSchema#string

Mohamed Hassanein

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Pierre P Massion

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Rosana Eisenberg

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William E Alborn

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P2860

Global cancer statistics

An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor

Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer

Bidirectional transport of amino acids regulates mTOR and autophagy

The NCI60 human tumour cell line anticancer drug screen

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity

Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

Protein expression profiling identifies macrophage migration inhibitory factor and cyclophilin a as potential molecular targets in non-small cell lung cancer.

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560-570

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10.1158/1078-0432.CCR-12-2334

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3

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19

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2012-12-04T00:00:00Z

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23213057

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3697078

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