Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines.
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mRNA transcripts initiating within the human immunoglobulin mu heavy chain enhancer region contain a non-translatable exon and are extremely heterogeneous at the 5' endSomatic mutations in the Ig variable region genes and expression of novel Cmu-germline transcripts in a B-lymphoma cell line ("Farage") not producing Ig polypeptide chains.IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c-myc expressionAn immunoglobulin mutator that targets G.C base pairs.Rapid induction of IgM-secreting murine plasmacytomas by pristane and an immunoglobulin heavy-chain promoter/enhancer-driven c-myc/v-Ha-ras retrovirus.Eleven distinct VH gene families and additional patterns of sequence variation suggest a high degree of immunoglobulin gene complexity in a lower vertebrate, Xenopus laevis.Light-chain gene expression before heavy-chain gene rearrangement in pre-B cells transformed by Epstein-Barr virusSecondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching.VH gene family utilization in colonies derived from B and pre-B cells detected by the RNA colony blot assaySeparate elements control DJ and VDJ rearrangement in a transgenic recombination substrateBone marrow pre-B lymphocytes synthesize immunoglobulin mu chains of membrane type with different properties and intracellular pathways.Chromosome translocation activates heterogeneously initiated, bipolar transcription of a mouse c-myc gene.Chromosome translocations clustered 5' of the murine c-myc gene qualitatively affect promoter usage: implications for the site of normal c-myc regulationSimultaneous expression of mu- and gamma-chain mRNA in cloned murine B-lymphoma cell lines.Synthesis of two mRNAs by utilization of alternate polyadenylation sites: expression of SV40-mouse immunoglobulin mu chain gene recombinants in Cos monkey cells.Activation of immunoglobulin mu gene expression involves stepwise demethylation.TCR beta and TCR alpha gene enhancers confer tissue- and stage-specificity on V(D)J recombination events.Regulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.Germ line transcription of the immunoglobulin heavy chain locus directs production of mu chain without VDJ.Epstein-Barr virus-transformed pro-B cells are prone to illegitimate recombination between the switch region of the mu chain gene and other chromosomesEarly rearrangements of genes encoding murine immunoglobulin kappa chains, unlike genes encoding heavy chains, use variable gene segments dispersed throughout the locus.Shared idiotypes and restricted immunoglobulin variable region heavy chain genes characterize murine autoantibodies of various specificities.Allelic inclusion in a pre-B-cell line that generates immunoglobulin heavy chain genes in vitroTranscriptional and posttranscriptional control of immunoglobulin mRNA production during B lymphocyte development.Pro-B cells sense productive immunoglobulin heavy chain rearrangement irrespective of polypeptide production.A novel germ-line JK transcript starting immediately upstream of JK1Evidence for transient requirement of the IgH enhancerCell-type-specific and regulated expression of a human gamma 1 heavy-chain immunoglobulin gene in transgenic mice.The genomic organization of immunoglobulin VH genes in Xenopus laevis shows evidence for interspersion of familiesImmunoglobulin (Ig) mu, kappa transgenic mice express transgenic idiotype on endogenously rearranged IgM and IgA molecules by secretion of chimeric moleculesA pattern of partially homologous recombination in mouse L cells.Allelic inclusion in the pre-B-cell line 18-81.Expression of immunoglobulin heavy chain at a high level in the absence of a proposed immunoglobulin enhancer element in cis.Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusionsRegulated expression of an immunoglobulin kappa gene introduced into a mouse lymphoid cell line.Long-term cultures of murine fetal liver retain very early B lymphoid phenotype.Induction of immunoglobulin isotype switching in cultured I.29 B lymphoma cells. Characterization of the accompanying rearrangements of heavy chain genes.Biased expression of JH-proximal VH genes occurs in the newly generated repertoire of neonatal and adult mice.Truncated mu (mu') chains in murine IgM. Evidence that mu' chains lack variable regions.Rearrangement and expression of T cell antigen receptor and gamma genes during thymic development
P2860
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P2860
Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines.
description
1982 nî lūn-bûn
@nan
1982年の論文
@ja
1982年論文
@yue
1982年論文
@zh-hant
1982年論文
@zh-hk
1982年論文
@zh-mo
1982年論文
@zh-tw
1982年论文
@wuu
1982年论文
@zh
1982年论文
@zh-cn
name
Multiple immunoglobulin heavy- ...... ansformed lymphoid cell lines.
@en
type
label
Multiple immunoglobulin heavy- ...... ansformed lymphoid cell lines.
@en
prefLabel
Multiple immunoglobulin heavy- ...... ansformed lymphoid cell lines.
@en
P2093
P2860
P356
P1476
Multiple immunoglobulin heavy- ...... ansformed lymphoid cell lines.
@en
P2093
P2860
P304
P356
10.1128/MCB.2.4.386
P407
P577
1982-04-01T00:00:00Z