CRTH2 antagonism significantly ameliorates airway hyperreactivity and downregulates inflammation-induced genes in a mouse model of airway inflammation.
about
Treatment of allergic asthma: modulation of Th2 cells and their responsesPGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2The prostaglandin D₂ receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge.D prostanoid receptor 2 (chemoattractant receptor-homologous molecule expressed on TH2 cells) protein expression in asthmatic patients and its effects on bronchial epithelial cellsLeukotriene E4 activates human Th2 cells for exaggerated proinflammatory cytokine production in response to prostaglandin D2.Antagonism of CRTH2 ameliorates chronic epicutaneous sensitization-induced inflammation by multiple mechanismsA small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation.Two Phase II randomized trials on the CRTh2 antagonist AZD1981 in adults with asthmaProstaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells.Novel CRTH2 antagonists: a review of patents from 2006 to 2009.Experimental advances in understanding allergic airway inflammation.Glucocorticoid-resistant asthma: more than meets the eye.A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma.Targeting the PGD2/CRTH2/DP1 Signaling Pathway in Asthma and Allergic Disease: Current Status and Future Perspectives.Prostaglandin D2 receptor antagonists in early development as potential therapeutic options for asthma.Biochemical and pharmacological characterization of AZD1981, an orally available selective DP2 antagonist in clinical development for asthma.DP2 (CRTh2) antagonism reduces ocular inflammation induced by allergen challenge and respiratory syncytial virus.The CRTH2 agonist Pyl A prevents lipopolysaccharide-induced fetal death but induces preterm labour.Elevated levels of circulating CD4(+) CRTh2(+) T cells characterize severe asthma.Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) antagonists in asthma: a systematic review and meta-analysis protocol.Efficacy and safety of the CRTh2 antagonist AZD1981 as add-on therapy to inhaled corticosteroids and long-acting β2-agonists in patients with atopic asthma.
P2860
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P2860
CRTH2 antagonism significantly ameliorates airway hyperreactivity and downregulates inflammation-induced genes in a mouse model of airway inflammation.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
CRTH2 antagonism significantly ...... model of airway inflammation.
@en
type
label
CRTH2 antagonism significantly ...... model of airway inflammation.
@en
prefLabel
CRTH2 antagonism significantly ...... model of airway inflammation.
@en
P2093
P2860
P1476
CRTH2 antagonism significantly ...... e model of airway inflammation
@en
P2093
Aaron A Berlin
Karin Franz-Bacon
Kevin B Bacon
L James Sprague
Nicholas W Lukacs
Roman Sásik
Stefen A Boehme
Tai Wei Ly
P2860
P304
P356
10.1152/AJPLUNG.90351.2008
P577
2008-08-29T00:00:00Z