Deconstructing voltage sensor function and pharmacology in sodium channels.
about
Phyla- and Subtype-Selectivity of CgNa, a Na Channel Toxin from the Venom of the Giant Caribbean Sea Anemone Condylactis GiganteaCrystallographic insights into sodium-channel modulation by the β4 subunitDiscovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models.Solution structure of GxTX-1E, a high-affinity tarantula toxin interacting with voltage sensors in Kv2.1 potassium channelsMapping the receptor site for alpha-scorpion toxins on a Na+ channel voltage sensorInteractions between lipids and voltage sensor paddles detected with tarantula toxinsThe hitchhiker's guide to the voltage-gated sodium channel galaxyFrom foe to friend: using animal toxins to investigate ion channel functionSodium leak channels in neuronal excitability and rhythmic behaviorsThe insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channelsA Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating DomainA distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1aDrosophila sodium channel mutations: Contributions to seizure-susceptibilitySelective spider toxins reveal a role for the Nav1.1 channel in mechanical painIndependent movement of the voltage sensors in KV2.1/KV6.4 heterotetramersMolecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendamiSynergetic action of domain II and IV underlies persistent current generation in Nav1.3 as revealed by a tarantula toxin.Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor.The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.Insect-Active Toxins with Promiscuous Pharmacology from the African Theraphosid Spider Monocentropus balfouriTransient and big are key features of an invertebrate T-type channel (LCav3) from the central nervous system of Lymnaea stagnalisTargeting voltage sensors in sodium channels with spider toxins.Localization of receptor site on insect sodium channel for depressant β-toxin BmK IT2Molecular determinants of coupling between the domain III voltage sensor and pore of a sodium channelDown-state model of the voltage-sensing domain of a potassium channel.Structure and orientation of a voltage-sensor toxin in lipid membranes.Inhibition of the activation pathway of the T-type calcium channel Ca(V)3.1 by ProTxII.Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins.Drosophila as a model for epilepsy: bss is a gain-of-function mutation in the para sodium channel gene that leads to seizures.Molecular Cloning and Sequence Analysis of the cDNAs Encoding Toxin-Like Peptides from the Venom Glands of Tarantula Grammostola rosea.Neurotoxins and their binding areas on voltage-gated sodium channels.Potassium Channels Blockers from the Venom of Androctonus mauretanicus mauretanicusThe tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation.A shaker K+ channel with a miniature engineered voltage sensor.Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cellsStructural interactions of a voltage sensor toxin with lipid membranes.Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart.Structure of membrane-active toxin from crab spider Heriaeus melloteei suggests parallel evolution of sodium channel gating modifiers in Araneomorphae and MygalomorphaeA surface plasmon resonance approach to monitor toxin interactions with an isolated voltage-gated sodium channel paddle motif.
P2860
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P2860
Deconstructing voltage sensor function and pharmacology in sodium channels.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Deconstructing voltage sensor function and pharmacology in sodium channels.
@en
type
label
Deconstructing voltage sensor function and pharmacology in sodium channels.
@en
prefLabel
Deconstructing voltage sensor function and pharmacology in sodium channels.
@en
P2093
P2860
P356
P1433
P1476
Deconstructing voltage sensor function and pharmacology in sodium channels.
@en
P2093
Frank Bosmans
Kenton J Swartz
Marie-France Martin-Eauclaire
P2860
P2888
P304
P356
10.1038/NATURE07473
P407
P577
2008-11-01T00:00:00Z
P5875
P6179
1008899056