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Deconstructing voltage sensor function and pharmacology in sodium channels.

Deconstructing voltage sensor function and pharmacology in sodium channels.

http://www.wikidata.org/entity/Q36983062

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Phyla- and Subtype-Selectivity of CgNa, a Na Channel Toxin from the Venom of the Giant Caribbean Sea Anemone Condylactis Gigantea Crystallographic insights into sodium-channel modulation by the β4 subunit Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models.Solution structure of GxTX-1E, a high-affinity tarantula toxin interacting with voltage sensors in Kv2.1 potassium channels Mapping the receptor site for alpha-scorpion toxins on a Na+ channel voltage sensor Interactions between lipids and voltage sensor paddles detected with tarantula toxins The hitchhiker's guide to the voltage-gated sodium channel galaxy From foe to friend: using animal toxins to investigate ion channel function Sodium leak channels in neuronal excitability and rhythmic behaviors The insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channels A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a Drosophila sodium channel mutations: Contributions to seizure-susceptibility Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain Independent movement of the voltage sensors in KV2.1/KV6.4 heterotetramers Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendami Synergetic action of domain II and IV underlies persistent current generation in Nav1.3 as revealed by a tarantula toxin.Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor.The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.Insect-Active Toxins with Promiscuous Pharmacology from the African Theraphosid Spider Monocentropus balfouri Transient and big are key features of an invertebrate T-type channel (LCav3) from the central nervous system of Lymnaea stagnalis Targeting voltage sensors in sodium channels with spider toxins.Localization of receptor site on insect sodium channel for depressant β-toxin BmK IT2 Molecular determinants of coupling between the domain III voltage sensor and pore of a sodium channel Down-state model of the voltage-sensing domain of a potassium channel.Structure and orientation of a voltage-sensor toxin in lipid membranes.Inhibition of the activation pathway of the T-type calcium channel Ca(V)3.1 by ProTxII.Gating-pore currents demonstrate selective and specific modulation of individual sodium channel voltage-sensors by biological toxins.Drosophila as a model for epilepsy: bss is a gain-of-function mutation in the para sodium channel gene that leads to seizures.Molecular Cloning and Sequence Analysis of the cDNAs Encoding Toxin-Like Peptides from the Venom Glands of Tarantula Grammostola rosea.Neurotoxins and their binding areas on voltage-gated sodium channels.Potassium Channels Blockers from the Venom of Androctonus mauretanicus mauretanicus The tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation.A shaker K+ channel with a miniature engineered voltage sensor.Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells Structural interactions of a voltage sensor toxin with lipid membranes.Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart.Structure of membrane-active toxin from crab spider Heriaeus melloteei suggests parallel evolution of sodium channel gating modifiers in Araneomorphae and Mygalomorphae A surface plasmon resonance approach to monitor toxin interactions with an isolated voltage-gated sodium channel paddle motif.

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P2860

Deconstructing voltage sensor function and pharmacology in sodium channels.

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2008 nî lūn-bûn

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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2008年论文

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name

Deconstructing voltage sensor function and pharmacology in sodium channels.

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Deconstructing voltage sensor function and pharmacology in sodium channels.

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Deconstructing voltage sensor function and pharmacology in sodium channels.

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Deconstructing voltage sensor function and pharmacology in sodium channels.

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Frank Bosmans

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Kenton J Swartz

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Marie-France Martin-Eauclaire

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P2860

X-ray structure of a voltage-dependent K+ channel

Portability of paddle motif function and pharmacology in voltage sensors

Tarantula toxins interact with voltage sensors within lipid membranes

Solution structure and functional characterization of SGTx1, a modifier of Kv2.1 channel gating

SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes

From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels

Generalized epilepsy with febrile seizures plus type 2 mutation W1204R alters voltage-dependent gating of Na(v)1.1 sodium channels

Pathomechanisms in channelopathies of skeletal muscle and brain

Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain

Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom

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202-208

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10.1038/NATURE07473

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