Total synthesis of natural (+)- [corrected] and ent-(-)-4-desacetoxy-6,7-dihydrovindorosine [corrected] and natural and ent-minovine: oxadiazole tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition reaction.
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Total synthesis of vinblastine, related natural products, and key analogues and development of inspired methodology suitable for the systematic study of their structure-function propertiesTotal synthesis of (+)-fendleridine (aspidoalbidine) and (+)-1-acetylaspidoalbidineTotal synthesis of lycogarubin C and lycogalic acid.Asymmetric total synthesis of vindolineBiomimetic Aerobic C-H Olefination of Cyclic Enaminones at Room Temperature: Development toward the Synthesis of 1,3,5-Trisubstituted Benzenes.Total synthesis and evaluation of a key series of C5-substituted vinblastine derivativesAsymmetric total synthesis of vindorosine, vindoline, and key vinblastine analoguesCatharanthine C16 substituent effects on the biomimetic coupling with vindoline: preparation and evaluation of a key series of vinblastine analogues.Cycloadditions of noncomplementary substituted 1,2,3-triazines.Scope of the inverse electron demand Diels-Alder reactions of 1,2,3-triazine.Inverse electron demand Diels-Alder reactions of 1,2,3-triazines: pronounced substituent effects on reactivity and cycloaddition scope10'-Fluorovinblastine and 10'-Fluorovincristine: Synthesis of a Key Series of Modified Vinca Alkaloids.Total synthesis of (-)-kopsinine and ent-(+)-kopsinineDivergent total syntheses of (-)-aspidospermine and (+)-spegazzinine.Cycloadditions of 1,2,3-Triazines Bearing C5-Electron Donating Substituents: Robust Pyrimidine SynthesisTotal Synthesis of (-)-Vindoline and (+)-4-epi-Vindoline Based on a 1,3,4-Oxadiazole Tandem Intramolecular [4 + 2]/[3 + 2] Cycloaddition Cascade Initiated by an Allene Dienophile.Total synthesis and evaluation of vinblastine analogues containing systematic deep-seated modifications in the vindoline subunit ring system: core redesign.A remarkable series of vinblastine analogues displaying enhanced activity and an unprecedented tubulin binding steric tolerance: C20' urea derivatives.Total synthesis of kopsinine.Total synthesis of (-)- and ent-(+)-vindoline and related alkaloids.Total synthesis of (-)- and ent-(+)-vindoline.Intramolecular diels-alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles.Potent Vinblastine C20' Ureas Displaying Additionally Improved Activity Against a Vinblastine-Resistant Cancer Cell Line.Total synthesis of vinblastine, vincristine, related natural products, and key structural analoguesTransannular Diels-Alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles: total synthesis of a unique set of vinblastine analogues.Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity.Total syntheses of (-)-kopsifoline D and (-)-deoxoapodine: divergent total synthesis via late-stage key strategic bond formation.Vinblastine 20' Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance.The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry-Biology Interface.Direct Synthesis of β-Aminoenals through Reaction of 1,2,3-Triazine with Secondary Amines.High expression of class III β-tubulin has no impact on functional cancer cell growth inhibition of a series of key vinblastine analogs.
P2860
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P2860
Total synthesis of natural (+)- [corrected] and ent-(-)-4-desacetoxy-6,7-dihydrovindorosine [corrected] and natural and ent-minovine: oxadiazole tandem intramolecular Diels-Alder/1,3-dipolar cycloaddition reaction.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Total synthesis of natural (+) ...... ipolar cycloaddition reaction.
@en
type
label
Total synthesis of natural (+) ...... ipolar cycloaddition reaction.
@en
prefLabel
Total synthesis of natural (+) ...... ipolar cycloaddition reaction.
@en
P2093
P2860
P356
P1433
P1476
Total synthesis of natural (+) ...... ipolar cycloaddition reaction.
@en
P2093
Dale L Boger
Hayato Ishikawa
Zhong Qing Yuan
P2860
P304
P356
10.1021/OL050017S
P407
P577
2005-02-01T00:00:00Z