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Total synthesis of vinblastine, related natural products, and key analogues and development of inspired methodology suitable for the systematic study of their structure-function propertiesSodium Bis(2-methoxyethoxy)aluminum HydrideTotal synthesis of (+)-fendleridine (aspidoalbidine) and (+)-1-acetylaspidoalbidineTotal synthesis of lycogarubin C and lycogalic acid.Asymmetric total synthesis of vindolineTotal synthesis and evaluation of a key series of C5-substituted vinblastine derivativesAsymmetric total synthesis of vindorosine, vindoline, and key vinblastine analoguesCatharanthine C16 substituent effects on the biomimetic coupling with vindoline: preparation and evaluation of a key series of vinblastine analogues.Straightforward protocol for the efficient synthesis of varied N(1)-acylated (aza)indole 2-/3-alkanoic acids and esters: optimization and scale-up.Inverse electron demand Diels-Alder reactions of 1,2,3-triazines: pronounced substituent effects on reactivity and cycloaddition scope10'-Fluorovinblastine and 10'-Fluorovincristine: Synthesis of a Key Series of Modified Vinca Alkaloids.Total synthesis of (-)-kopsinine and ent-(+)-kopsinineDivergent total syntheses of (-)-aspidospermine and (+)-spegazzinine.A Dipolar Cycloaddition Approach Toward the Kopsifoline Alkaloid Framework.Total Synthesis of (-)-Vindoline and (+)-4-epi-Vindoline Based on a 1,3,4-Oxadiazole Tandem Intramolecular [4 + 2]/[3 + 2] Cycloaddition Cascade Initiated by an Allene Dienophile.Total synthesis and evaluation of vinblastine analogues containing systematic deep-seated modifications in the vindoline subunit ring system: core redesign.Tandem Intramolecular Diels-Alder/1,3-Dipolar Cycloaddition Cascade of 1,3,4-Oxadiazoles: Initial Scope and Applications.A remarkable series of vinblastine analogues displaying enhanced activity and an unprecedented tubulin binding steric tolerance: C20' urea derivatives.Total synthesis of kopsinine.Cycloaddition protocol for the assembly of the hexacyclic framework associated with the kopsifoline alkaloids.Total synthesis of (-)- and ent-(+)-vindoline and related alkaloids.Direct coupling of catharanthine and vindoline to provide vinblastine: total synthesis of (+)- and ent-(-)-vinblastineIntramolecular diels-alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles.Application of the Rh(II) cyclization/cycloaddition cascade for the total synthesis of (+/-)-aspidophytine.Potent Vinblastine C20' Ureas Displaying Additionally Improved Activity Against a Vinblastine-Resistant Cancer Cell Line.Total synthesis of vinblastine, vincristine, related natural products, and key structural analoguesTransannular Diels-Alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles: total synthesis of a unique set of vinblastine analogues.Total synthesis of a key series of vinblastines modified at C4 that define the importance and surprising trends in activity.Total syntheses of (-)-kopsifoline D and (-)-deoxoapodine: divergent total synthesis via late-stage key strategic bond formation.Vinblastine 20' Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance.Inverse-Electron-Demand Diels-Alder Reactions: Principles and Applications.Formation and Trapping of Azafulvene Intermediates Derived from Manganese-Mediated Oxidative Malonate Coupling.The Difference a Single Atom Can Make: Synthesis and Design at the Chemistry-Biology Interface.Total Synthesis of (-)-Vindorosine.High expression of class III β-tubulin has no impact on functional cancer cell growth inhibition of a series of key vinblastine analogs.Stereoselective construction of a key hydroindole precursor of epidithiodiketopiperazine (ETP) natural products.Sodium Bis(2-methoxyethoxy)aluminum HydrideBis(trimethylsilyl) PeroxideBis(trimethylsilyl) Peroxide
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Total synthesis of (-)- and ent-(+)-vindoline.
@en
type
label
Total synthesis of (-)- and ent-(+)-vindoline.
@en
prefLabel
Total synthesis of (-)- and ent-(+)-vindoline.
@en
P2093
P2860
P356
P1433
P1476
Total synthesis of (-)- and ent-(+)-vindoline.
@en
P2093
Dale L Boger
Gregory I Elliott
Hayato Ishikawa
Juraj Velcicky
Michael M Miller
Younggi Choi
P2860
P304
P356
10.1021/OL051975X
P407
P577
2005-09-01T00:00:00Z