Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells.
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Elevation and persistence of CD8 T-cells in HIV infection: the Achilles heel in the ART eraMolecular and cellular insights into T cell exhaustionOvercoming T cell exhaustion in infection and cancerInnate and Adaptive Immune Regulation During Chronic Viral InfectionsMechanisms of Virologic Control and Clinical Characteristics of HIV+ Elite/Viremic ControllersT-bet and Eomes are differentially linked to the exhausted phenotype of CD8+ T cells in HIV infectionProgrammed death-1 expression on HIV-1-specific CD8+ T cells is shaped by epitope specificity, T-cell receptor clonotype usage and antigen load.Expansion of dysfunctional Tim-3-expressing effector memory CD8+ T cells during simian immunodeficiency virus infection in rhesus macaquesT cell exhaustion during persistent viral infections.Epigenetic modulations in activated cells early after HIV-1 infection and their possible functional consequences.Memory CD8 T cell transcriptional plasticity.Hypomethylation and up-regulation of PD-1 in T cells by azacytidine in MDS/AML patients: A rationale for combined targeting of PD-1 and DNA methylation.Exhaustion of Activated CD8 T Cells Predicts Disease Progression in Primary HIV-1 Infection.HIV-specific CD8⁺ T cells and HIV eradicationCD8+ T cells undergo activation and programmed death-1 repression in the liver of aged Ae2a,b-/- mice favoring autoimmune cholangitisPD-1 expression conditions T cell avidity within an antigen-specific repertoire.Costimulatory and Coinhibitory Receptor Pathways in Infectious DiseaseAsymptomatic memory CD8+ T cells: from development and regulation to consideration for human vaccines and immunotherapeuticsDemethylation of the PD-1 Promoter Is Imprinted during the Effector Phase of CD8 T Cell Exhaustion.Generating long-lived CD8(+) T-cell memory: Insights from epigenetic programs.Variations in DNA methylation of interferon gamma and programmed death 1 in allograft rejection after kidney transplantation.PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumors.Tolerance and exhaustion: defining mechanisms of T cell dysfunction.Epigenetic Signatures as Biomarkers of Exposure.Maintenance of PD-1 on brain-resident memory CD8 T cells is antigen independent.Genetic and Epigenetic Regulation of PD-1 ExpressionReversing T-cell Dysfunction and Exhaustion in Cancer.Novel immunological strategies for HIV-1 eradicationCell-Intrinsic Barriers of T Cell-Based Immunotherapy.STAT3, STAT4, NFATc1, and CTCF regulate PD-1 through multiple novel regulatory regions in murine T cells.T-Cell Receptor (TCR) Clonotype-Specific Differences in Inhibitory Activity of HIV-1 Cytotoxic T-Cell Clones Is Not Mediated by TCR Alone.Conserved Region C Functions To Regulate PD-1 Expression and Subsequent CD8 T Cell Memory.Programming T cell Killers for an HIV Cure: Teach the New Dogs New Tricks and Let the Sleeping Dogs LieTranscriptional and epigenetic regulation of T cell hyporesponsiveness.Exhaustion-associated regulatory regions in CD8+ tumor-infiltrating T cells."Hep C, where art thou": What are the remaining (fundable) questions in hepatitis C virus research?TCR independent suppression of CD8(+) T cell cytokine production mediated by IFNγ in vivo.Type I interferon signaling enhances CD8+ T cell effector function and differentiation during murine gammaherpesvirus 68 infection.CD8+ memory T cells appear exhausted within hours of acute virus infection.Immune checkpoint blockade in infectious diseases.
P2860
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P2860
Cutting edge: Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Cutting edge: Prolonged exposu ...... in virus-specific CD8 T cells.
@en
type
label
Cutting edge: Prolonged exposu ...... in virus-specific CD8 T cells.
@en
prefLabel
Cutting edge: Prolonged exposu ...... in virus-specific CD8 T cells.
@en
P2093
P2860
P50
P356
P1476
Cutting edge: Prolonged exposu ...... in virus-specific CD8 T cells.
@en
P2093
Alessandra Noto
Ben Youngblood
Daniel E Kaufmann
Filippos Porichis
Francesco A Procopio
James W Austin
Jeremy M Boss
John Sidney
Rafi Ahmed
Rafick-Pierre Sékaly
P2860
P304
P356
10.4049/JIMMUNOL.1203161
P407
P577
2013-06-14T00:00:00Z