Selective A(3) adenosine receptor antagonists derived from nucleosides containing a bicyclo[3.1.0]hexane ring system.
about
Recent developments in adenosine receptor ligands and their potential as novel drugsStructural probing of off-target G protein-coupled receptor activities within a series of adenosine/adenine congenersEvaluation of homology modeling of G-protein-coupled receptors in light of the A(2A) adenosine receptor crystallographic structure.Synthesis and pharmacological characterization of [(125)I]MRS5127, a high affinity, selective agonist radioligand for the A3 adenosine receptor2-Dialkynyl derivatives of (N)-methanocarba nucleosides: 'Clickable' A(3) adenosine receptor-selective agonists.Synthesis and evaluation of N⁶-substituted apioadenosines as potential adenosine A₃ receptor modulators.Extended N(6) substitution of rigid C2-arylethynyl nucleosides for exploring the role of extracellular loops in ligand recognition at the A3 adenosine receptor.Predicted structures of agonist and antagonist bound complexes of adenosine A3 receptorFunctionalized congeners of A3 adenosine receptor-selective nucleosides containing a bicyclo[3.1.0]hexane ring system.Truncated (N)-Methanocarba Nucleosides as A(1) Adenosine Receptor Agonists and Partial Agonists: Overcoming Lack of a Recognition ElementMethanocarba ring as a ribose modification in ligands of G protein-coupled purine and pyrimidine receptors: synthetic approaches.Medicinal chemistry of the A3 adenosine receptor: agonists, antagonists, and receptor engineering.Introduction to adenosine receptors as therapeutic targets.Structural sweet spot for A1 adenosine receptor activation by truncated (N)-methanocarba nucleosides: receptor docking and potent anticonvulsant activityTruncated Nucleosides as A(3) Adenosine Receptor Ligands: Combined 2-Arylethynyl and Bicyclohexane SubstitutionsRegio- and stereoselective synthesis of truncated 3'-aminocarbanucleosides and their binding affinity at the A3 adenosine receptor.Synthesis and characterization of [76Br]-labeled high-affinity A3 adenosine receptor ligands for positron emission tomography.Rational design of sulfonated A3 adenosine receptor-selective nucleosides as pharmacological tools to study chronic neuropathic pain.Synthesis and anti-renal fibrosis activity of conformationally locked truncated 2-hexynyl-N(6)-substituted-(N)-methanocarba-nucleosides as A3 adenosine receptor antagonists and partial agonists.The A3 adenosine receptor as multifaceted therapeutic target: pharmacology, medicinal chemistry, and in silico approaches.A3 Adenosine Receptors as Modulators of Inflammation: From Medicinal Chemistry to Therapy.Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters.New selective A2A agonists and A3 antagonists for human adenosine receptors: synthesis, biological activity and molecular docking studies
P2860
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P2860
Selective A(3) adenosine receptor antagonists derived from nucleosides containing a bicyclo[3.1.0]hexane ring system.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Selective A(3) adenosine recep ...... yclo[3.1.0]hexane ring system.
@en
type
label
Selective A(3) adenosine recep ...... yclo[3.1.0]hexane ring system.
@en
prefLabel
Selective A(3) adenosine recep ...... yclo[3.1.0]hexane ring system.
@en
P2093
P2860
P50
P1476
Selective A(3) adenosine recep ...... yclo[3.1.0]hexane ring system.
@en
P2093
Artem Melman
Bhalchandra V Joshi
Cara L Heller
Lak Shin Jeong
Soo-Kyung Kim
P2860
P304
P356
10.1016/J.BMC.2008.08.007
P407
P577
2008-08-07T00:00:00Z