Unexpected mechanisms of action for a cytokine receptor-blocking antibody.

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Unexpected mechanisms of action for a cytokine receptor-blocking antibody.

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2014 nî lūn-bûn

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2014年の論文

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2014年論文

@yue

2014年論文

@zh-hant

2014年論文

@zh-hk

2014年論文

@zh-mo

2014年論文

@zh-tw

2014年论文

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2014年论文

@zh

2014年论文

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Unexpected mechanisms of action for a cytokine receptor-blocking antibody.

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Unexpected mechanisms of action for a cytokine receptor-blocking antibody.

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Unexpected mechanisms of action for a cytokine receptor-blocking antibody.

@en

P1476

Unexpected mechanisms of action for a cytokine receptor-blocking antibody

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P2093

Angel F Lopez

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Matthew P Hardy

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Michael W Parker

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Nicholas J Wilson

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Sophie E Broughton

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P2860

Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody

The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells

Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells

The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling.

Targeting of acute myeloid leukaemia by cytokine-induced killer cells redirected with a novel CD123-specific chimeric antigen receptor.

Molecular basis of cytokine receptor activation.

Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells.

Monoclonal antibody 7G3 recognizes the N-terminal domain of the human interleukin-3 (IL-3) receptor alpha-chain and functions as a specific IL-3 receptor antagonist.

Targeting of acute myeloid leukemia in vitro and in vivo with an anti-CD123 mAb engineered for optimal ADCC.

Elevated expression of IL-3Ralpha in acute myelogenous leukemia is associated with enhanced blast proliferation, increased cellularity, and poor prognosis.

P304

e969129

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P31

scholarly article

P356

10.4161/23288604.2014.969129

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P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

P50

Timothy R Hercus

Tracy L Nero

P577

2014-10-01T00:00:00Z

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P5875

276159628

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P698

27308368

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P932

4905208

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