Monoclonal antibody 7G3 recognizes the N-terminal domain of the human interleukin-3 (IL-3) receptor alpha-chain and functions as a specific IL-3 receptor antagonist.
about
Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity bindingCytokines in asthma.Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancerEnumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis.Overexpression of IL-3Rα on CD34+CD38- stem cells defines leukemia-initiating cells in Fanconi anemia AML.Efficacy of an Fc-modified anti-CD123 antibody (CSL362) combined with chemotherapy in xenograft models of acute myelogenous leukemia in immunodeficient mice.The Shc-binding site of the betac subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesisAutocrine production and action of IL-3 and granulocyte colony-stimulating factor in chronic myeloid leukemia.Unexpected mechanisms of action for a cytokine receptor-blocking antibody.Investigating cell surface markers on normal hematopoietic stem cells in three different niche conditionsImmunotherapy of acute leukemia by chimeric antigen receptor-modified lymphocytes using an improved Sleeping Beauty transposon platform.Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362.CD 123 is a membrane biomarker and a therapeutic target in hematologic malignancies.CD123 target validation and preclinical evaluation of ADCC activity of anti-CD123 antibody CSL362 in combination with NKs from AML patients in remission.Expression of functional interleukin-3 receptors on Hodgkin and Reed-Sternberg cellsAntibody darts on target for acute myelogenous leukemia.Targeting IL-5Rα with antibody-conjugates reveals a strategy for imaging and therapy for invasive bladder cancer.A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.Balance of Anti-CD123 Chimeric Antigen Receptor Binding Affinity and Density for the Targeting of Acute Myeloid Leukemia.
P2860
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P2860
Monoclonal antibody 7G3 recognizes the N-terminal domain of the human interleukin-3 (IL-3) receptor alpha-chain and functions as a specific IL-3 receptor antagonist.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Monoclonal antibody 7G3 recogn ...... ific IL-3 receptor antagonist.
@en
type
label
Monoclonal antibody 7G3 recogn ...... ific IL-3 receptor antagonist.
@en
prefLabel
Monoclonal antibody 7G3 recogn ...... ific IL-3 receptor antagonist.
@en
P2093
P1433
P1476
Monoclonal antibody 7G3 recogn ...... ific IL-3 receptor antagonist.
@en
P2093
Goodall GJ
Korpelainen EI
Rapoport A
Stomski FC
P407
P577
1996-01-01T00:00:00Z