Novel insights about the MDM2/MDM4 heterodimer. - Wikidata - wikimedia - TriplyDB

Novel insights about the MDM2/MDM4 heterodimer.

Novel insights about the MDM2/MDM4 heterodimer.

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Peptides and peptidomimetics in the p53/MDM2/MDM4 circuitry - a patent review.

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Novel insights about the MDM2/MDM4 heterodimer.

http://www.wikidata.org/entity/Q36997995

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2015 nî lūn-bûn

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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2015年论文

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name

Novel insights about the MDM2/MDM4 heterodimer.

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label

Novel insights about the MDM2/MDM4 heterodimer.

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prefLabel

Novel insights about the MDM2/MDM4 heterodimer.

@en

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23723556.2015.1066923

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Molecular & cellular oncology

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Novel insights about the MDM2/MDM4 heterodimer.

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Fabiola Moretti

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P2860

MDM4 (MDMX) localizes at the mitochondria and facilitates the p53-mediated intrinsic-apoptotic pathway

Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damage

MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response

MDM4 is a key therapeutic target in cutaneous melanoma.

Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases

MDM2's social network.

The Mdm network and its regulation of p53 activities: a rheostat of cancer risk.

MDM4 enhances p53 stability by promoting an active conformation of the protein upon DNA damage.

Nuclear and cytoplasmic degradation of endogenous p53 and HDM2 occurs during down-regulation of the p53 response after multiple types of DNA damage.

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e1066923

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scholarly article

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10.1080/23723556.2015.1066923

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2

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2015-08-20T00:00:00Z

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27308591

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4905374

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