A human TRIM5alpha B30.2/SPRY domain mutant gains the ability to restrict and prematurely uncoat B-tropic murine leukemia virus.
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Paleovirology--modern consequences of ancient virusesStructure of the rhesus monkey TRIM5 PRYSPRY domain, the HIV capsid recognition moduleStructural insight into HIV-1 capsid recognition by rhesus TRIM5Fates of retroviral core components during unrestricted and TRIM5-restricted infectionA rare null allele potentially encoding a dominant-negative TRIM5alpha protein in Baka pygmiesCharacterization of a core fragment of the rhesus monkey TRIM5α protein.The specificity of TRIM5 alpha-mediated restriction is influenced by its coiled-coil domain.Effects of human SAMHD1 polymorphisms on HIV-1 susceptibility.MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1Contribution of SAM and HD domains to retroviral restriction mediated by human SAMHD1.The retroviral restriction ability of SAMHD1, but not its deoxynucleotide triphosphohydrolase activity, is regulated by phosphorylationA novel aminoacid determinant of HIV-1 restriction in the TRIM5α variable 1 region isolated in a random mutagenic screenHomology-based identification of capsid determinants that protect HIV1 from human TRIM5α restrictionElevated rate of fixation of endogenous retroviral elements in Haplorhini TRIM5 and TRIM22 genomic sequences: impact on transcriptional regulation.BI-2 destabilizes HIV-1 cores during infection and Prevents Binding of CPSF6 to the HIV-1 CapsidThe fate of HIV-1 capsid: a biochemical assay for HIV-1 uncoatingTrafficking of some old world primate TRIM5α proteins through the nucleus.Unique spectrum of activity of prosimian TRIM5alpha against exogenous and endogenous retrovirusesContribution of MxB oligomerization to HIV-1 capsid binding and restrictionRole of TRIM5α RING domain E3 ubiquitin ligase activity in capsid disassembly, reverse transcription blockade, and restriction of simian immunodeficiency virus.Contribution of E3-ubiquitin ligase activity to HIV-1 restriction by TRIM5alpha(rh): structure of the RING domain of TRIM5alpha.RING domain mutations uncouple TRIM5α restriction of HIV-1 from inhibition of reverse transcription and acceleration of uncoatingSJP-L-5, a novel small-molecule compound, inhibits HIV-1 infection by blocking viral DNA nuclear entry.Restriction of HIV-1 Requires the N-Terminal Region of MxB as a Capsid-Binding Motif but Not as a Nuclear Localization SignalRING Dimerization Links Higher-Order Assembly of TRIM5α to Synthesis of K63-Linked Polyubiquitin.TNPO3 is required for HIV-1 replication after nuclear import but prior to integration and binds the HIV-1 core.Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmac.Contribution of SUMO-interacting motifs and SUMOylation to the antiretroviral properties of TRIM5α.Inhibition of reverse transcriptase activity increases stability of the HIV-1 core.The ability of TNPO3-depleted cells to inhibit HIV-1 infection requires CPSF6.Virus-specific effects of TRIM5α(rh) RING domain functions on restriction of retroviruses.Target cell type-dependent modulation of human immunodeficiency virus type 1 capsid disassembly by cyclophilin A.Differential contribution of basic residues to HIV-1 nucleocapsid protein's nucleic acid chaperone function and retroviral replication.Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity.The small-molecule 3G11 inhibits HIV-1 reverse transcription.MxB Is Not Responsible for the Blocking of HIV-1 Infection Observed in Alpha Interferon-Treated Cells.Contribution of oligomerization to the anti-HIV-1 properties of SAMHD1.A novel envelope mediated post entry restriction of murine leukaemia virus in human cells is Ref1/TRIM5α independent.HIV-1 Capsid Stabilization Assay.Binding of the rhesus TRIM5α PRYSPRY domain to capsid is necessary but not sufficient for HIV-1 restriction.
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P2860
A human TRIM5alpha B30.2/SPRY domain mutant gains the ability to restrict and prematurely uncoat B-tropic murine leukemia virus.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 30 June 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A human TRIM5alpha B30.2/SPRY ...... -tropic murine leukemia virus.
@en
A human TRIM5alpha B30.2/SPRY ...... -tropic murine leukemia virus.
@nl
type
label
A human TRIM5alpha B30.2/SPRY ...... -tropic murine leukemia virus.
@en
A human TRIM5alpha B30.2/SPRY ...... -tropic murine leukemia virus.
@nl
prefLabel
A human TRIM5alpha B30.2/SPRY ...... -tropic murine leukemia virus.
@en
A human TRIM5alpha B30.2/SPRY ...... -tropic murine leukemia virus.
@nl
P2093
P2860
P1433
P1476
A human TRIM5alpha B30.2/SPRY ...... -tropic murine leukemia virus.
@en
P2093
Didier Trono
Felipe Diaz-Griffero
Kathleen McGee-Estrada
Michel Perron
Robert Hanna
P2860
P304
P356
10.1016/J.VIROL.2008.05.008
P407
P577
2008-06-30T00:00:00Z