Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer.
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Targeting Notch to overcome radiation resistanceStructure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations.Protein trafficking abnormalities in Drosophila tissues with impaired activity of the ZIP7 zinc transporter CatsupNOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB.FHL1C induces apoptosis in Notch1-dependent T-ALL cells through an interaction with RBP-J.An aquaporin 3-notch1 axis in keratinocyte differentiation and inflammationCancer as a channelopathy: ion channels and pumps in tumor development and progressionPERK Limits Drosophila Lifespan by Promoting Intestinal Stem Cell Proliferation in Response to ER Stress.A novel Monoclonal Antibody against Notch1 Targets Leukemia-associated Mutant Notch1 and Depletes Therapy Resistant Cancer Stem Cells in Solid Tumors.Direct detection of SERCA calcium transport and small-molecule inhibition in giant unilamellar vesicles.SBF-1 exerts strong anticervical cancer effect through inducing endoplasmic reticulum stress-associated cell death via targeting sarco/endoplasmic reticulum Ca(2+)-ATPase 2Signal integration by Ca(2+) regulates intestinal stem-cell activity.Small molecule RL71 targets SERCA2 at a novel site in the treatment of human colorectal cancer.Ca(2+) monitoring in Plasmodium falciparum using the yellow cameleon-Nano biosensor.The clerodane diterpene casearin J induces apoptosis of T-ALL cells through SERCA inhibition, oxidative stress, and interference with Notch1 signaling.Calcium-ATPases: Gene disorders and dysregulation in cancer.MicroRNA-275 targets sarco/endoplasmic reticulum Ca2+ adenosine triphosphatase (SERCA) to control key functions in the mosquito gut.Therapeutic modulation of Notch signalling--are we there yet?New Approaches to Target T-ALL.Pleiotropic roles of Notch signaling in normal, malignant, and developmental hematopoiesis in the human.Targeting childhood, adolescent and young adult non-Hodgkin lymphoma: therapeutic horizons.Human NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17.Cab45S promotes cell proliferation through SERCA2b inhibition and Ca2+ signaling.4H-Chromene-based anticancer agents towards multi-drug resistant HL60/MX2 human leukemia: SAR at the 4th and 6th positions.Calcium role in human carcinogenesis: a comprehensive analysis and critical review of literature.Loss of IP3R-dependent Ca2+ signalling in thymocytes leads to aberrant development and acute lymphoblastic leukemia.A novel SERCA inhibitor demonstrates synergy with classic SERCA inhibitors and targets multidrug-resistant AML.Aberrant Signaling Pathways in T-Cell Acute Lymphoblastic Leukemia.Use of Hes1-GFP reporter mice to assess activity of the Hes1 promoter in bone cells under chronic inflammation.Small-molecule RL71-triggered excessive autophagic cell death as a potential therapeutic strategy in triple-negative breast cancer.The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia.Mechanism of BMP9 promotes growth of osteosarcoma mediated by the Notch signaling pathway.A Report of Two Patients with Darier Disease and Hidradenitis Suppurativa.MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia.Leukemia-specific delivery of mutant NOTCH1 targeted therapy.DEPTOR is a direct NOTCH1 target that promotes cell proliferation and survival in T-cell leukemia.Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channel.Bepridil exhibits anti-leukemic activity associated with NOTCH1 pathway inhibition in chronic lymphocytic leukemia.Targeting Notch-Activated M1 Macrophages Attenuates Joint Tissue Damage in a Mouse Model of Inflammatory Arthritis.NOTCH1 Aberrations in Chronic Lymphocytic Leukemia.
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Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 21 February 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Complementary genomic screens ...... rget in NOTCH1 mutated cancer.
@en
Complementary genomic screens ...... rget in NOTCH1 mutated cancer.
@nl
type
label
Complementary genomic screens ...... rget in NOTCH1 mutated cancer.
@en
Complementary genomic screens ...... rget in NOTCH1 mutated cancer.
@nl
prefLabel
Complementary genomic screens ...... rget in NOTCH1 mutated cancer.
@en
Complementary genomic screens ...... rget in NOTCH1 mutated cancer.
@nl
P2093
P2860
P50
P1433
P1476
Complementary genomic screens ...... rget in NOTCH1 mutated cancer.
@en
P2093
Angela H Su
Giovanni Roti
Jon C Aster
Kenneth N Ross
Kostandin Pajcini
Stephen C Blacklow
Warren S Pear
P2860
P304
P356
10.1016/J.CCR.2013.01.015
P577
2013-02-21T00:00:00Z