Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy.
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Sudden unexpected death in epilepsy: fatal post-ictal respiratory and arousal mechanismsLoss of CENP-F results in distinct microtubule-related defects without chromosomal abnormalities.Inhibiting cholesterol degradation induces neuronal sclerosis and epileptic activity in mouse hippocampus.Spreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP modelsTau Protein Mediates APP Intracellular Domain (AICD)-Induced Alzheimer's-Like Pathological Features in MiceThe dendritic hypothesis for Alzheimer's disease pathophysiology.Mechanisms of sudden unexplained death in epilepsyModeling Alzheimer's disease in mouse without mutant protein overexpression: cooperative and independent effects of Aβ and tauAlphaScreen HTS and live-cell bioluminescence resonance energy transfer (BRET) assays for identification of Tau-Fyn SH3 interaction inhibitors for Alzheimer disease.Seizure resistance without parkinsonism in aged mice after tau reductionHyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segment.Tau association with synaptic vesicles causes presynaptic dysfunction.Phosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture.Motor and cognitive deficits in aged tau knockout mice in two background strains.Tau reduction diminishes spatial learning and memory deficits after mild repetitive traumatic brain injury in mice.Tau reduction prevents disease in a mouse model of Dravet syndromePro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulationTau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β.Network dysfunction in α-synuclein transgenic mice and human Lewy body dementia.Riluzole rescues glutamate alterations, cognitive deficits, and tau pathology associated with P301L tau expressionEarly rescue of interneuron disease trajectory in developmental epilepsies.Mechanisms of tau and Aβ-induced excitotoxicity.Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice.The Tau/A152T mutation, a risk factor for frontotemporal-spectrum disorders, leads to NR2B receptor-mediated excitotoxicity.Pathway-driven discovery of epilepsy genes.Riluzole rescues alterations in rapid glutamate transients in the hippocampus of rTg4510 mice.Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase.Antisense reduction of tau in adult mice protects against seizuresSudden unexpected death in epilepsy genetics: Molecular diagnostics and preventionGenomic biomarkers of SUDEP in brain and heart.Epilepsy in the elderly: Special considerations and challenges.Single-Gene Determinants of Epilepsy Comorbidity.Epileptic activity in Alzheimer's disease: causes and clinical relevance.Antisense Oligonucleotides: Translation from Mouse Models to Human Neurodegenerative Diseases.Novel function of Tau in regulating the effects of external stimuli on adult hippocampal neurogenesis.Bexarotene reduces network excitability in models of Alzheimer's disease and epilepsy.Recurrent Epileptic Auras As a Presenting Symptom of Alzheimer's Disease.The Wanderer Falters: Central Vagal Dysregulation Triggers SUDEP.Tau exacerbates excitotoxic brain damage in an animal model of stroke.One Mutation Deserves Another in the Quest for Antiepileptogenesis.
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Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on January 2013
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Tau loss attenuates neuronal n ...... la genetic models of epilepsy.
@en
Tau loss attenuates neuronal n ...... la genetic models of epilepsy.
@nl
type
label
Tau loss attenuates neuronal n ...... la genetic models of epilepsy.
@en
Tau loss attenuates neuronal n ...... la genetic models of epilepsy.
@nl
prefLabel
Tau loss attenuates neuronal n ...... la genetic models of epilepsy.
@en
Tau loss attenuates neuronal n ...... la genetic models of epilepsy.
@nl
P2093
P2860
P1476
Tau loss attenuates neuronal n ...... ila genetic models of epilepsy
@en
P2093
J Graham Reed
Jerrah K Holth
Juan Botas
Linda Younkin
Robia G Pautler
Steven G Younkin
Taeko Inoue
Valerie C Bomben
P2860
P304
P356
10.1523/JNEUROSCI.3191-12.2013
P407
P577
2013-01-01T00:00:00Z