Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice.
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Tau StructuresPhosphorylation of tau at Y18, but not tau-fyn binding, is required for tau to modulate NMDA receptor-dependent excitotoxicity in primary neuronal culture.The Tau/A152T mutation, a risk factor for frontotemporal-spectrum disorders, leads to NR2B receptor-mediated excitotoxicity.Increased 4R-Tau Induces Pathological Changes in a Human-Tau Mouse Model.Positive and negative early life experiences differentially modulate long term survival and amyloid protein levels in a mouse model of Alzheimer's disease.A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction.Stress-Induced Synaptic Dysfunction and Neurotransmitter Release in Alzheimer's Disease: Can Neurotransmitters and Neuromodulators be Potential Therapeutic Targets?The Role of the Carboxyl-Terminal Sequence of Tau and MAP2 in the Pathogenesis of DementiaEpileptic activity in Alzheimer's disease: causes and clinical relevance.Targeting Neural Hyperactivity as a Treatment to Stem Progression of Late-Onset Alzheimer's Disease.Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability.Relative Incidence of Seizures and Myoclonus in Alzheimer's Disease, Dementia with Lewy Bodies, and Frontotemporal Dementia.Human TAUP301L overexpression results in TAU hyperphosphorylation without neurofibrillary tangles in adult zebrafish brainTauopathy induced by low level expression of a human brain-derived tau fragment in mice is rescued by phenylbutyrate.Hippocampal neurophysiology is modified by a disease-associated C-terminal fragment of tau protein.Practical considerations for choosing a mouse model of Alzheimer's disease.Tauopathies: Mechanisms and Therapeutic Strategies.Interplay of pathogenic forms of human tau with different autophagic pathways.Zebrafish as an Animal Model for Drug Discovery in Parkinson's Disease and Other Movement Disorders: A Systematic Review.Tau-Induced Pathology in Epilepsy and Dementia: Notions from Patients and Animal Models.
P2860
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P2860
Expression of A152T human tau causes age-dependent neuronal dysfunction and loss in transgenic mice.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
Expression of A152T human tau ...... n and loss in transgenic mice.
@ast
Expression of A152T human tau ...... n and loss in transgenic mice.
@en
type
label
Expression of A152T human tau ...... n and loss in transgenic mice.
@ast
Expression of A152T human tau ...... n and loss in transgenic mice.
@en
prefLabel
Expression of A152T human tau ...... n and loss in transgenic mice.
@ast
Expression of A152T human tau ...... n and loss in transgenic mice.
@en
P2093
P2860
P356
P1433
P1476
Expression of A152T human tau ...... n and loss in transgenic mice.
@en
P2093
Allyson Davis
Biljana Djukic
Daniel Kim
Gui-Qiu Yu
Lennart Mucke
Praveen Taneja
Ravikumar Ponnusamy
Ryan Craft
Sumihiro Maeda
P2860
P304
P356
10.15252/EMBR.201541438
P577
2016-03-01T00:00:00Z