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Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery.

Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery.

http://www.wikidata.org/entity/Q37018993

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IMP dehydrogenase: structure, mechanism, and inhibition.A heterocyclic molecule with significant activity against dengue virus Bacillus anthracis Inosine 5′-Monophosphate Dehydrogenase in Action: The First Bacterial Series of Structures of Phosphate Ion-, Substrate-, and Product-Bound Complexes Increased riboflavin production by manipulation of inosine 5'-monophosphate dehydrogenase in Ashbya gossypii Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation A screening pipeline for antiparasitic agents targeting cryptosporidium inosine monophosphate dehydrogenase Two classes of bacterial IMPDHs according to their quaternary structures and catalytic properties Triazole inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase Synthesis of carbocyclic nucleoside analogs with five-membered heterocyclic nucleobases.Inosine monophosphate dehydrogenase as a target for antiviral, anticancer, antimicrobial and immunosuppressive therapeutics.The dynamic determinants of reaction specificity in the IMPDH/GMPR family of (β/α)(8) barrel enzymes.Synthesis of the inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitors.Base-functionalized carbocyclic nucleosides: design, synthesis, and mechanism of antiviral activity.Antiviral activity of an N-allyl acridone against dengue virus Synthesis and evaluation of N-substituted acridones as antiviral agents against haemorrhagic fever viruses.Carbocyclic analogues of inosine-5'-monophosphate: synthesis and biological activity.A kinetic alignment of orthologous inosine-5'-monophosphate dehydrogenases.Ultrastructure of cytoplasmic and nuclear inosine-5'-monophosphate dehydrogenase 2 "rods and rings" inclusions.Glutamine deprivation initiates reversible assembly of mammalian rods and rings.Conserved water mediated recognition and the dynamics of active site Cys 331 and Tyr 411 in hydrated structure of human IMPDH-II.Synthesis of novel aza-analogues of tiazofurin with 2-[5,5-bis(hydroxymethyl)pyrrolidin-2-yl] framework as sugar mimic.Fragment-Based Approach to Targeting Inosine-5'-monophosphate Dehydrogenase (IMPDH) from Mycobacterium tuberculosis.Newer human inosine 5'-monophosphate dehydrogenase 2 (hIMPDH2) inhibitors as potential anticancer agents.

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Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery.

http://www.wikidata.org/entity/Q37018993

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on January 2007

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery.

@en

Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery.

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type

label

Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery.

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Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery.

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prefLabel

Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery.

@en

Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery.

@nl

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095632020701800501

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Antiviral Chemistry & Chemotherapy

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Inosine monophosphate dehydrogenase as a probe in antiviral drug discovery.

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Qingning Shu

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Vasu Nair

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P2860

RNA virus error catastrophe: direct molecular test by using ribavirin

Mutations in the inosine monophosphate dehydrogenase 1 gene (IMPDH1) cause the RP10 form of autosomal dominant retinitis pigmentosa.

Targeted disruption of the inosine 5'-monophosphate dehydrogenase type I gene in mice

Broad-spectrum antiviral activity of 2-beta-D-ribofuranosylselenazole-4-carboxamide, a new antiviral agent

Crystal structure of human type II inosine monophosphate dehydrogenase: implications for ligand binding and drug design

Crystal structure of a ternary complex of Tritrichomonas foetus inosine 5'-monophosphate dehydrogenase: NAD+ orients the active site loop for catalysis

Recombinant human inosine monophosphate dehydrogenase type I and type II proteins. Purification and characterization of inhibitor binding

Ribavirin--current status of a broad spectrum antiviral agent

In vitro and in vivo influenza virus-inhibitory effects of viramidine

New hypoxanthine nucleosides with RNA antiviral activity

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245-258

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scholarly article

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10.1177/095632020701800501

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5

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18046958

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