TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation.
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Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammationA Review of Biomarkers in Mood and Psychotic Disorders: A Dissection of Clinical vs. Preclinical CorrelatesThe TNF-family cytokine TL1A: from lymphocyte costimulator to disease co-conspiratorMembrane trafficking of death receptors: implications on signallingIntestinal Antigen-Presenting Cells: Key Regulators of Immune Homeostasis and InflammationImmunopathology of inflammatory bowel diseaseOn death receptor 3 and its ligands…A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonistGenetic predictors of medically refractory ulcerative colitisInflammatory bowel diseaseGenetic variation in IBD: progress, clues to pathogenesis and possible clinical utilityThe role of tumor necrosis factor receptor superfamily members in mammalian brain development, function and homeostasisIBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein.Comprehensive linkage and association analyses identify haplotype, near to the TNFSF15 gene, significantly associated with spondyloarthritisThe role of T cell PPAR gamma in mice with experimental inflammatory bowel disease.TLR8-mediated activation of human monocytes inhibits TL1A expression.Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosisTumour necrosis factor superfamily members in the pathogenesis of inflammatory bowel diseaseThe TNF-like protein 1A-death receptor 3 pathway promotes macrophage foam cell formation in vitro.Age-dependent maintenance of motor control and corticostriatal innervation by death receptor 3.Insights into IBD Pathogenesis.Two functionally distinct isoforms of TL1A (TNFSF15) generated by differential ectodomain sheddingA TNFSF15 disease-risk polymorphism increases pattern-recognition receptor-induced signaling through caspase-8-induced IL-1.Inhibition of a novel fibrogenic factor Tl1a reverses established colonic fibrosis.Use of animal models in elucidating disease pathogenesis in IBD.Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation.TL1-A can engage death receptor-3 and activate NF-kappa B in endothelial cells.Perturbations of mucosal homeostasis through interactions of intestinal microbes with myeloid cells.c-Myc is essential to prevent endothelial pro-inflammatory senescent phenotype.Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization.Central role of IL-17/Th17 immune responses and the gut microbiota in the pathogenesis of intestinal fibrosisChronic intestinal inflammation alters hippocampal neurogenesis.A major population of mucosal memory CD4+ T cells, coexpressing IL-18Rα and DR3, display innate lymphocyte functionalityHMPL-004 (Andrographis paniculata extract) prevents development of murine colitis by inhibiting T-cell proliferation and TH1/TH17 responsesCD161 DEFINES EFFECTOR T CELLS THAT EXPRESS LIGHT AND RESPOND TO TL1A-DR3 SIGNALING.Over-Expression of CD200 Protects Mice from Dextran Sodium Sulfate Induced ColitisPrevalence of genetic variants associated with inflammatory bowel disease in a healthy First Nations cohortConstitutive TL1A expression under colitogenic conditions modulates the severity and location of gut mucosal inflammation and induces fibrostenosis.mTOR Inhibition Attenuates Dextran Sulfate Sodium-Induced Colitis by Suppressing T Cell Proliferation and Balancing TH1/TH17/Treg ProfileFine-mapping analysis revealed complex pleiotropic effect and tissue-specific regulatory mechanism of TNFSF15 in primary biliary cholangitis, Crohn's disease and leprosy.
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TL1A (TNFSF15) regulates the development of chronic colitis by modulating both T-helper 1 and T-helper 17 activation.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 07 May 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
TL1A (TNFSF15) regulates the d ...... 1 and T-helper 17 activation.
@en
TL1A
@nl
type
label
TL1A (TNFSF15) regulates the d ...... 1 and T-helper 17 activation.
@en
TL1A
@nl
prefLabel
TL1A (TNFSF15) regulates the d ...... 1 and T-helper 17 activation.
@en
TL1A
@nl
P2093
P2860
P1433
P1476
TL1A (TNFSF15) regulates the d ...... r 1 and T-helper 17 activation
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P2093
Carol J Landers
Deepti Dhall
Jonathan Braun
Kathrin S Michelsen
Lisa S Thomas
Stephan R Targan
P2860
P304
P356
10.1053/J.GASTRO.2008.04.037
P407
P577
2008-05-07T00:00:00Z