Targeting cancer with a lupus autoantibody - Wikidata - wikimedia - TriplyDB

Targeting cancer with a lupus autoantibody

Targeting cancer with a lupus autoantibody

http://www.wikidata.org/entity/Q37019392

about

DNA-damaging autoantibodies and cancer: the lupus butterfly theory.Novel tools for prostate cancer prognosis, diagnosis, and follow-up Disruption of CD8+ Treg activity results in expansion of T follicular helper cells and enhanced antitumor immunity.DNA-dependent targeting of cell nuclei by a lupus autoantibody.Malignancies in systemic lupus erythematosus: a 2015 update.Defective DNA repair and chromatin organization in patients with quiescent systemic lupus erythematosus.Lymphoma risk in systemic lupus: effects of disease activity versus treatment Functional consequences of complementarity-determining region deactivation in a multifunctional anti-nucleic acid antibody.Breast cancer in systemic lupus erythematosus.A lupus anti-DNA autoantibody mediates autocatalytic, targeted delivery of nanoparticles to tumors.A nucleolytic lupus autoantibody is toxic to BRCA2-deficient cancer cells.Lung, liver, prostate, bladder malignancies risk in systemic lupus erythematosus: evidence from a meta-analysis.New horizons in therapeutic antibody discovery: opportunities and challenges versus small-molecule therapeutics.Getting across the cell membrane: an overview for small molecules, peptides, and proteins.Perception of self: distinguishing autoimmunity from autoinflammation.Combining intracellular antibodies to restore function of mutated p53 in cancer.Can killers be saviors?Breast cancer in systemic lupus.Immunological evidence and regulatory potential for cell-penetrating antibodies in intravenous immunoglobulin.A cell-penetrating antibody inhibits human RAD51 via direct binding.Lupus antibody tops cancer cells.Increased DNA double-strand breaks and enhanced apoptosis in patients with lupus nephritis.Targeted Intracellular Delivery of Antibodies: The State of the Art

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Targeting cancer with a lupus autoantibody

http://www.wikidata.org/entity/Q37019392

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on October 2012

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

@da

vědecký článek

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name

Targeting cancer with a lupus autoantibody

@en

Targeting cancer with a lupus autoantibody.

@nl

type

label

Targeting cancer with a lupus autoantibody

@en

Targeting cancer with a lupus autoantibody.

@nl

prefLabel

Targeting cancer with a lupus autoantibody

@en

Targeting cancer with a lupus autoantibody.

@nl

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SCITRANSLMED.3004385

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Science Translational Medicine

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Targeting cancer with a lupus autoantibody

@en

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Denise C Hegan

http://www.w3.org/2001/XMLSchema#string

Elizabeth Peterson-Roth

http://www.w3.org/2001/XMLSchema#string

Eloise Dray

http://www.w3.org/2001/XMLSchema#string

Erik Geiger

http://www.w3.org/2001/XMLSchema#string

Grace Chan

http://www.w3.org/2001/XMLSchema#string

James E Hansen

http://www.w3.org/2001/XMLSchema#string

Joann B Sweasy

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Joseph Gera

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Patrick Sung

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Peter M Glazer

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P2860

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

Homologous recombination in DNA repair and DNA damage tolerance

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.

Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 protein.

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

The concept of synthetic lethality in the context of anticancer therapy

Rad52 inactivation is synthetically lethal with BRCA2 deficiency

BRCA2 is required for homology-directed repair of chromosomal breaks

Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130.

Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation.

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157ra142

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scholarly article

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10.1126/SCITRANSLMED.3004385

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157

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4

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2012-10-01T00:00:00Z

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232706164

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23100628

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