Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage.
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Therapeutic interventions against inflammatory and angiogenic mediators in proliferative diabetic retinopathyRho kinase proteins--pleiotropic modulators of cell survival and apoptosisER stress and apoptosis: a new mechanism for retinal cell death.Information exploration system for sickle cell disease and repurposing of hydroxyfasudilOxidative Stress-Related Mechanisms and Antioxidant Therapy in Diabetic RetinopathyMolecular Imaging of Retinal Endothelial Injury in Diabetic Animals.The role of rho kinase in sex-dependent vascular dysfunction in type 1 diabetes.Gene variations of ROCKs and risk of ischaemic stroke: the Women's Genome Health Study.Involvement of RhoA/ROCK1 signaling pathway in hyperglycemia-induced microvascular endothelial dysfunction in diabetic retinopathyAberrant ROCK activation promotes the development of type I diabetes in NOD miceActivation of ErbB2 and Downstream Signalling via Rho Kinases and ERK1/2 Contributes to Diabetes-Induced Vascular Dysfunction.Complex regulation of PKCβ2 and PDK-1/AKT by ROCK2 in diabetic heart.Wound contraction is attenuated by fasudil inhibition of Rho-associated kinaseThe Rho kinase inhibitor Y-27632 increases erythrocyte deformability and low oxygen tension-induced ATP release.Fasudil hydrochloride, a potent ROCK inhibitor, inhibits corneal neovascularization after alkali burns in miceMorphological Changes of Human Corneal Endothelial Cells after Rho-Associated Kinase Inhibitor Eye Drop (Ripasudil) Administration: A Prospective Open-Label Clinical Study.Elevated Glucose Levels Promote Contractile and Cytoskeletal Gene Expression in Vascular Smooth Muscle via Rho/Protein Kinase C and Actin PolymerizationRhoA/rock signaling mediates peroxynitrite-induced functional impairment of Rat coronary vesselsBlocking VEGF/Caveolin-1 signaling contributes to renal protection of fasudil in streptozotocin-induced diabetic ratsROCK inhibitor fasudil attenuated high glucose-induced MCP-1 and VCAM-1 expression and monocyte-endothelial cell adhesionEffects of K-115 (Ripasudil), a novel ROCK inhibitor, on trabecular meshwork and Schlemm's canal endothelial cells.Diabetes causes bone marrow endothelial barrier dysfunction by activation of the RhoA-Rho-associated kinase signaling pathway.Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout.Acute Rho-kinase inhibition improves coronary dysfunction in vivo, in the early diabetic microcirculationROCK1 reduces mitochondrial content and irisin production in muscle suppressing adipocyte browning and impairing insulin sensitivity.Lymphoblastoid Cell Lines as a Tool to Study Inter-Individual Differences in the Response to GlucoseThe Rho/Rho-associated protein kinase inhibitor fasudil in the protection of endothelial cells against advanced glycation end products through the nuclear factor κB pathway.Thromboxane A2 receptor activates a Rho-associated kinase/LKB1/PTEN pathway to attenuate endothelium insulin signaling.Targeting of Rho kinase ameliorates impairment of diabetic endothelial function in intrarenal artery.The Andes Virus Nucleocapsid Protein Directs Basal Endothelial Cell Permeability by Activating RhoA.Molecular mechanisms of endothelial hyperpermeability: implications in inflammation.ROCK-isoform-specific polarization of macrophages associated with age-related macular degeneration.Endothelial contractile cytoskeleton and microvascular permeability.Long-term diabetic complications may be ameliorated by targeting Rho kinase.Inflammation in diabetic retinopathy.Acute and sustained actions of hyperglycaemia on endothelial and glomerular barrier permeability.Targeting endothelial dysfunction in vascular complications associated with diabetes.Rho-kinase inhibitors offer a new approach in the treatment of glaucoma.Intravitreal fasudil combined with bevacizumab for treatment of refractory diabetic macular edema; a pilot study.RhoA/mDia-1/profilin-1 signaling targets microvascular endothelial dysfunction in diabetic retinopathy.
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P2860
Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage.
description
article científic
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article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 07 October 2008
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vedecký článok
@sk
vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage.
@en
Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage.
@nl
type
label
Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage.
@en
Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage.
@nl
prefLabel
Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage.
@en
Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage.
@nl
P2093
P2860
P356
P1433
P1476
Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage.
@en
P2093
Ali Hafezi-Moghadam
Faryan Tayyari
Hiroaki Shimokawa
Lama Almulki
Muneki Miura
Ryoichi Arita
Shintaro Nakao
Shuhei Kawahara
Souska Zandi
Takeshi Kita
P2860
P304
P356
10.2337/DB08-0762
P407
P577
2008-10-07T00:00:00Z