The genetics and biology of Irf5-mediated signaling in lupus.
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Overview of the biology of type I interferonsDistinct regulation of murine lupus susceptibility genes by the IRF5/Blimp-1 axisGenetic risk factors in lupus nephritis and IgA nephropathy--no support of an overlap.IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosusContribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus.Gender-dependent expression of murine Irf5 gene: implications for sex bias in autoimmunityGenetic associations in type I interferon related pathways with autoimmunity4F decreases IRF5 expression and activation in hearts of tight skin mice.RNA-Seq for enrichment and analysis of IRF5 transcript expression in SLE.The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis.Vicious circle: systemic autoreactivity in Ro52/TRIM21-deficient miceGenetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosus.Cell type and gender-dependent differential regulation of the p202 and Aim2 proteins: implications for the regulation of innate immune responses in SLE.Differential requirement of histone acetylase and deacetylase activities for IRF5-mediated proinflammatory cytokine expression.Emerging roles for the interferon-inducible p200-family proteins in sex bias in systemic lupus erythematosus.Interferons in autoimmune and inflammatory diseases: regulation and roles.Effects of IRF5 lupus risk haplotype on pathways predicted to influence B cell functionsInterferon-inducible Ifi200-family genes as modifiers of lupus susceptibility.Genetics of myasthenia gravis: a case-control association study in the Hellenic population.Genetics of SLE: functional relevance for monocytes/macrophages in diseaseCytokines in systemic lupus erythematosusUnique contribution of IRF-5-Ikaros axis to the B-cell IgG2a response.Irf5-deficient mice are protected from pristane-induced lupus via increased Th2 cytokines and altered IgG class switching.The search for lupus biomarkers.Estradiol targets T cell signaling pathways in human systemic lupus.Genetics of the type I interferon pathway in systemic lupus erythematosus.Type I IFNs and their role in the development of autoimmune diseases.Novel insights on the role of the innate immune system in systemic sclerosis.Interferon regulatory factor 5 in the pathogenesis of systemic lupus erythematosus.Use of biomarkers in the management of children with lupus.Interferon regulatory factor 5 and autoimmune lupus.Epigenetics and the IRFs: a complex interplay in the control of immunity and autoimmunity.Genetic, genomic and epigenetic studies as tools for elucidating disease pathogenesis in primary Sjögren's syndrome.Cardiovascular disease complications in systemic lupus erythematosus.Associations between interferon regulatory factor 5 polymorphisms and rheumatoid arthritis: a meta-analysis.
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The genetics and biology of Irf5-mediated signaling in lupus.
description
article científic
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article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on December 2007
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
The genetics and biology of Irf5-mediated signaling in lupus.
@en
The genetics and biology of Irf5-mediated signaling in lupus.
@nl
type
label
The genetics and biology of Irf5-mediated signaling in lupus.
@en
The genetics and biology of Irf5-mediated signaling in lupus.
@nl
prefLabel
The genetics and biology of Irf5-mediated signaling in lupus.
@en
The genetics and biology of Irf5-mediated signaling in lupus.
@nl
P2860
P1433
P1476
The genetics and biology of Irf5-mediated signaling in lupus.
@en
P2093
Sergey V Kozyrev
P2860
P304
P356
10.1080/08916930701510905
P577
2007-12-01T00:00:00Z