Deletions of the hypervariable region (HVR) in open reading frame 1 of hepatitis E virus do not abolish virus infectivity: evidence for attenuation of HVR deletion mutants in vivo.
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Hepatitis E Virus Mutations: Functional and Clinical RelevanceHepatitis E PathogenesisMolecular Biology and Infection of Hepatitis E VirusZoonotic Hepatitis E Virus: Classification, Animal Reservoirs and Transmission RoutesEmerging and re-emerging swine virusesEvolution of the hepatitis E virus hypervariable region.Hepatitis E virus: animal reservoirs and zoonotic riskNaturally occurring animal models of human hepatitis E virus infection.The hepatitis E virus polyproline region is involved in viral adaptationConstruction of an infectious cDNA clone of avian hepatitis E virus (avian HEV) recovered from a clinically healthy chicken in the United States and characterization of its pathogenicity in specific-pathogen-free chickens.The nucleotides on the stem-loop RNA structure in the junction region of the hepatitis E virus genome are critical for virus replication.Molecular biology and replication of hepatitis E virus.Cross-species infections of cultured cells by hepatitis E virus and discovery of an infectious virus-host recombinant.Intergenotypic chimeric hepatitis E viruses (HEVs) with the genotype 4 human HEV capsid gene in the backbone of genotype 3 swine HEV are infectious in pigs.Three amino acid mutations (F51L, T59A, and S390L) in the capsid protein of the hepatitis E virus collectively contribute to virus attenuation.Mutational analysis of the hypervariable region of hepatitis e virus reveals its involvement in the efficiency of viral RNA replicationThe lysine residues within the human ribosomal protein S17 sequence naturally inserted into the viral nonstructural protein of a unique strain of hepatitis E virus are important for enhanced virus replication.Adaptation of a genotype 3 hepatitis E virus to efficient growth in cell culture depends on an inserted human gene segment acquired by recombination.A naturally occurring human/hepatitis E recombinant virus predominates in serum but not in faeces of a chronic hepatitis E patient and has a growth advantage in cell culture.Ancient recombination events and the origins of hepatitis E virusEvolution of the hepatitis E virus polyproline region: order from disorder.Cross-species infection of pigs with a novel rabbit, but not rat, strain of hepatitis E virus isolated in the United StatesRescue of a genotype 4 human hepatitis E virus from cloned cDNA and characterization of intergenotypic chimeric viruses in cultured human liver cells and in pigs.Hepatitis E virus: foodborne, waterborne and zoonotic transmission.The hepatitis E virus nonstructural polyprotein.Heparan sulfate proteoglycans are required for cellular binding of the hepatitis E virus ORF2 capsid protein and for viral infection.HEV Cell Culture.Genetic Evolution of Hepatitis E Virus.Determination of the full-genome sequence of hepatitis E virus (HEV) SAAS-FX17 and use as a reference to identify putative HEV genotype 4 virulence determinants.Characterization of the polyproline region of the hepatitis E virus in immunocompromised patients.Influence of polyproline region and macro domain genetic heterogeneity on HEV persistence in immunocompromised patients.Full-length sequence analysis of hepatitis E virus isolates: showing potential determinants of virus genotype and identity.Serological prevalence, genetic identification, and characterization of the first strains of avian hepatitis E virus from chickens in Korea.Identification of GBF1 as a cellular factor required for hepatitis E virus RNA replication.Zoonotic Hepatitis E Virus: An Ignored Risk for Public Health.Substitution of amino acid residue V1213 in the helicase domain of the genotype 3 hepatitis E virus reduces virus replication.Molecular Analysis and Modeling of Hepatitis E Virus Helicase and Identification of Novel Inhibitors by Virtual Screening
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Deletions of the hypervariable region (HVR) in open reading frame 1 of hepatitis E virus do not abolish virus infectivity: evidence for attenuation of HVR deletion mutants in vivo.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 22 October 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Deletions of the hypervariable ...... HVR deletion mutants in vivo.
@en
Deletions of the hypervariable region
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type
label
Deletions of the hypervariable ...... HVR deletion mutants in vivo.
@en
Deletions of the hypervariable region
@nl
prefLabel
Deletions of the hypervariable ...... HVR deletion mutants in vivo.
@en
Deletions of the hypervariable region
@nl
P2093
P2860
P356
P1433
P1476
Deletions of the hypervariable ...... f HVR deletion mutants in vivo
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P2093
F W Pierson
P G Halbur
T Opriessnig
P2860
P304
P356
10.1128/JVI.01854-08
P407
P577
2008-10-22T00:00:00Z