Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells
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IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIVTranscriptional control of HIV latency: cellular signaling pathways, epigenetics, happenstance and the hope for a cureRecent developments in human immunodeficiency virus-1 latency researchUnderstanding HIV latency: the road to an HIV cureEpigenetic regulation of HIV-1 latency by cytosine methylationPhosphorylation of CDK9 at Ser175 enhances HIV transcription and is a marker of activated P-TEFb in CD4(+) T lymphocytesHistone deacetylase inhibitor romidepsin induces HIV expression in CD4 T cells from patients on suppressive antiretroviral therapy at concentrations achieved by clinical dosing.An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patientsDirectly infected resting CD4+T cells can produce HIV Gag without spreading infection in a model of HIV latencyHomeostatic proliferation fails to efficiently reactivate HIV-1 latently infected central memory CD4+ T cells.CpG methylation controls reactivation of HIV from latency.HIV-1 Vpr triggers natural killer cell-mediated lysis of infected cells through activation of the ATR-mediated DNA damage responseSmall-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activationCombinatorial signals from CD28 differentially regulate human immunodeficiency virus transcription in T cellsNegative elongation factor is required for the maintenance of proviral latency but does not induce promoter-proximal pausing of RNA polymerase II on the HIV long terminal repeat.Ruxolitinib and tofacitinib are potent and selective inhibitors of HIV-1 replication and virus reactivation in vitro.Quantification of HIV-1 latency reversal in resting CD4+ T cells from patients on suppressive antiretroviral therapySmall molecule inhibition of HIV-1-induced MHC-I down-regulation identifies a temporally regulated switch in Nef actionAn HIV-encoded antisense long noncoding RNA epigenetically regulates viral transcription.Benzotriazoles Reactivate Latent HIV-1 through Inactivation of STAT5 SUMOylation.HIV persistence: chemokines and their signalling pathways.Mechanisms of HIV Transcriptional Regulation by Drugs of Abuse.Combinatorial latency reactivation for HIV-1 subtypes and variantsTranscriptional and posttranscriptional regulation of HIV-1 gene expressionBET bromodomain inhibition as a novel strategy for reactivation of HIV-1Combination of biological screening in a cellular model of viral latency and virtual screening identifies novel compounds that reactivate HIV-1Replication competent virus as an important source of bias in HIV latency models utilizing single round viral constructs.A flexible model of HIV-1 latency permitting evaluation of many primary CD4 T-cell reservoirs.Establishment of HIV-1 latency in resting CD4+ T cells depends on chemokine-induced changes in the actin cytoskeleton.Nonhuman primate models for HIV cure research.Degranulation of natural killer cells following interaction with HIV-1-infected cells is hindered by downmodulation of NTB-A by Vpu.The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit.Finding a cure for HIV: will it ever be achievable?Towards an HIV cure: a global scientific strategyDendritic cell-induced activation of latent HIV-1 provirus in actively proliferating primary T lymphocytesShort chain fatty acids potently induce latent HIV-1 in T-cells by activating P-TEFb and multiple histone modifications.Attenuated Listeria monocytogenes vectors overcome suppressive plasma factors during HIV infection to stimulate myeloid dendritic cells to promote adaptive immunity and reactivation of latent virus.Calcium/calcineurin synergizes with prostratin to promote NF-κB dependent activation of latent HIVHigh-throughput screening uncovers a compound that activates latent HIV-1 and acts cooperatively with a histone deacetylase (HDAC) inhibitor.Myeloid dendritic cells induce HIV-1 latency in non-proliferating CD4+ T cells.
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P2860
Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells
description
article científic
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article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 10 October 2008
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells
@en
Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells.
@nl
type
label
Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells
@en
Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells.
@nl
prefLabel
Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells
@en
Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells.
@nl
P2860
P1433
P1476
Induction of HIV-1 latency and reactivation in primary memory CD4+ T cells
@en
P2093
Vicente Planelles
P2860
P356
10.1182/BLOOD-2008-07-168393
P407
P577
2008-10-10T00:00:00Z