Laforin prevents stress-induced polyglucosan body formation and Lafora disease progression in neurons.

Laforin prevents stress-induced polyglucosan body formation and Lafora disease progression in neurons.

Item
http://www.wikidata.org/entity/Q37043068
Does abnormal glycogen structure contribute to increased susceptibility to seizures in epilepsy?Activation of serum/glucocorticoid-induced kinase 1 (SGK1) underlies increased glycogen levels, mTOR activation, and autophagy defects in Lafora disease.Laforin-malin complex degrades polyglucosan bodies in concert with glycogen debranching enzyme and brain isoform glycogen phosphorylaseA novel image-based high-throughput screening assay discovers therapeutic candidates for adult polyglucosan body disease.Glycogen synthase protects neurons from cytotoxicity of mutant huntingtin by enhancing the autophagy flux.Triacylglycerol mimetics regulate membrane interactions of glycogen branching enzyme: implications for therapy.Polyglucosan neurotoxicity caused by glycogen branching enzyme deficiency can be reversed by inhibition of glycogen synthase.
P2860

Laforin prevents stress-induced polyglucosan body formation and Lafora disease progression in neurons.

Item
http://www.wikidata.org/entity/Q37043068
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 02 April 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Laforin prevents stress-induce ...... isease progression in neurons.
@en
Laforin prevents stress-induce ...... isease progression in neurons.
@nl
type
label
Laforin prevents stress-induce ...... isease progression in neurons.
@en
Laforin prevents stress-induce ...... isease progression in neurons.
@nl
prefLabel
Laforin prevents stress-induce ...... isease progression in neurons.
@en
Laforin prevents stress-induce ...... isease progression in neurons.
@nl
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P1476
P2093
P2860
P2888
P304
P31
P356
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P478
P577
P698
P932
P356
P1433
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Laforin prevents stress-induce ...... isease progression in neurons.
@en
P2093
P2860
P2888
P304
P31
P356
P433
P478
P577
P698
P932