Epm2a suppresses tumor growth in an immunocompromised host by inhibiting Wnt signaling
about
A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's diseaseMalin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG)Laforin, the most common protein mutated in Lafora disease, regulates autophagyLaforin is required for the functional activation of malin in endoplasmic reticulum stress resistance in neuronal cellsLaforin is a glycogen phosphatase, deficiency of which leads to elevated phosphorylation of glycogen in vivo.Laforin, a dual specificity phosphatase involved in Lafora disease, is present mainly as monomeric form with full phosphatase activityNF1 inactivation in adult acute myelogenous leukemiaTargeting HIF1α eliminates cancer stem cells in hematological malignancies.Laforin, a dual-specificity phosphatase involved in Lafora disease, is phosphorylated at Ser25 by AMP-activated protein kinase.Malin regulates Wnt signaling pathway through degradation of dishevelled2Laforin, a protein with many faces: glucan phosphatase, adapter protein, et alii.HSP90 inhibitor 17-AAG selectively eradicates lymphoma stem cells.Neuronatin-mediated aberrant calcium signaling and endoplasmic reticulum stress underlie neuropathology in Lafora diseaseDevelopment of a clinically feasible molecular assay to predict recurrence of stage II colon cancer.Laforin confers cancer resistance to energy deprivation-induced apoptosis.Lafora disease, seizures and sugars.Laforin negatively regulates cell cycle progression through glycogen synthase kinase 3beta-dependent mechanisms.Laforin prevents stress-induced polyglucosan body formation and Lafora disease progression in neurons.Protein tyrosine phosphatases: dual-specificity phosphatases in health and disease.Glycogen and its metabolism: some new developments and old themes.B7 blockade alters the balance between regulatory T cells and tumor-reactive T cells for immunotherapy of cancerDeletions and missense mutations of EPM2A exacerbate unfolded protein response and apoptosis of neuronal cells induced by endoplasm reticulum stressHyperphosphorylation and aggregation of Tau in laforin-deficient mice, an animal model for Lafora disease.Lafora disease: insights into neurodegeneration from plant metabolism.Laforin-malin complex degrades polyglucosan bodies in concert with glycogen debranching enzyme and brain isoform glycogen phosphorylasePhenotype variations in Lafora progressive myoclonus epilepsy: possible involvement of genetic modifiers?Regulation of glycogen synthesis by the laforin-malin complex is modulated by the AMP-activated protein kinase pathway.Dimerization of Laforin is required for its optimal phosphatase activity, regulation of GSK3beta phosphorylation, and Wnt signaling.Elucidating human phosphatase-substrate networks.Wnt Signaling in Hematological Malignancies.
P2860
Q24295313-6BE58D9E-D5C4-401B-9FC9-CDA420EBA703Q24302550-E102146D-5CFE-4308-97BC-A6FC7DA6ACA8Q24311181-AA575333-0B49-42B0-BFAA-015D92BD4779Q24320315-7A5F60FB-C38C-40C8-984E-7053607C3944Q30441600-33F8A91D-4016-4C71-BCFE-9235AA343D9CQ34009801-F84BE512-B0CE-4B3B-98AD-351E4ADE598AQ34065032-DB5CA5F3-D60D-4404-B0C2-E55785CABB78Q34887224-E570EA7E-E1D5-4637-8E12-1E728EA14A6FQ35821706-BEAF8E92-73C7-4355-BAD4-BBAEB9EAB68CQ35838878-49025E2A-B950-4A14-BF20-F60EDD869775Q36020483-7451FFA4-D7BC-4B7C-A354-81D116B598C3Q36237528-E29488AE-ABD0-4EA1-A4D9-121CC07AAD8DQ36725125-E0FE4A5A-ABDD-4B78-8893-6878C818E475Q36734636-1EF61EDE-538A-47C2-8D7C-317C92EEBCDBQ36738183-3B6A4D81-4060-473E-B534-94DB3CFAD081Q36960383-4115AE2F-F3DE-439F-B363-6519F1716AB3Q36994751-02D8E6E8-04E6-4F7A-9BA0-2C3E7FC7675AQ37043068-B249F76D-724C-47AA-9D66-87C897EB7FE4Q37094068-9ECEFD93-DD5C-4B0F-B4B0-C4332CD7AEECQ37095413-275D85FE-0252-4DFF-A705-A415CF840EECQ37221274-D381BEAA-81CF-42B8-A8AA-9122B791368DQ37239891-DC429555-F32C-426F-8054-EB5D4F4B2D80Q37371631-40A6044A-F0A1-4308-8884-16790807B89DQ37612219-AC24D656-0B0B-41F9-8B93-7284FABC360AQ37638387-BF384FD9-D885-4C2F-8080-CDC86CBAB39EQ37997914-B900F721-9462-4B7E-9632-DB576749EB2DQ40047094-72990FB5-5612-4E0D-980F-B23D7850596AQ40232391-3D6F323F-E2B1-4827-A158-E5770E4F2C69Q42599269-6E766E9A-FD61-4F5B-AF94-81EB16B9FE07Q49493229-E118AB1C-F8E2-4875-AAA6-CADCC1F98502
P2860
Epm2a suppresses tumor growth in an immunocompromised host by inhibiting Wnt signaling
description
2006 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im September 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/09/01)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/09/01)
@nl
наукова стаття, опублікована у вересні 2006
@uk
مقالة علمية (نشرت في سبتمبر 2006)
@ar
name
Epm2a suppresses tumor growth in an immunocompromised host by inhibiting Wnt signaling
@ast
Epm2a suppresses tumor growth in an immunocompromised host by inhibiting Wnt signaling
@en
Epm2a suppresses tumor growth in an immunocompromised host by inhibiting Wnt signaling
@nl
type
label
Epm2a suppresses tumor growth in an immunocompromised host by inhibiting Wnt signaling
@ast
Epm2a suppresses tumor growth in an immunocompromised host by inhibiting Wnt signaling
@en
Epm2a suppresses tumor growth in an immunocompromised host by inhibiting Wnt signaling
@nl
prefLabel
Epm2a suppresses tumor growth in an immunocompromised host by inhibiting Wnt signaling
@ast
Epm2a suppresses tumor growth in an immunocompromised host by inhibiting Wnt signaling
@en
Epm2a suppresses tumor growth in an immunocompromised host by inhibiting Wnt signaling
@nl
P2093
P1433
P1476
Epm2a suppresses tumor growth in an immunocompromised host by inhibiting Wnt signaling
@en
P2093
Gerard J. Nuovo
Huiming Zhang
Terrence L. Geiger
Xincheng Zheng
P304
P356
10.1016/J.CCR.2006.08.008
P577
2006-09-01T00:00:00Z