Translocon "pulling" of nascent SecM controls the duration of its translational pause and secretion-responsive secA regulation
about
Genetic identification of nascent peptides that induce ribosome stalling.SecM-stalled ribosomes adopt an altered geometry at the peptidyl transferase center.SecM facilitates translocase function of SecA by localizing its biosynthesisCotranslational Protein Folding inside the Ribosome Exit Tunnel.Recruitment of a species-specific translational arrest module to monitor different cellular processes.The translational regulatory function of SecM requires the precise timing of membrane targeting.Mechanisms of integral membrane protein insertion and foldingStructure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stallingNascent SecM chain outside the ribosome reinforces translation arrestMechanisms of SecM-mediated stalling in the ribosomeDissecting structures and functions of SecA-only protein-conducting channels: ATPase, pore structure, ion channel activity, protein translocation, and interaction with SecYEG/SecDF•YajC.Mechanisms of ribosome stalling by SecM at multiple elongation steps.Mutations in the Escherichia coli ribosomal protein L22 selectively suppress the expression of a secreted bacterial virulence factor.Cotranslational folding of membrane proteins probed by arrest-peptide-mediated force measurements.The plasticity of a translation arrest motif yields insights into nascent polypeptide recognition inside the ribosome tunnelThe Expression of Antibiotic Resistance Methyltransferase Correlates with mRNA Stability Independently of Ribosome Stalling.A ribosome-nascent chain sensor of membrane protein biogenesis in Bacillus subtilis.Translation arrest of SecM is essential for the basal and regulated expression of SecA.Divergent stalling sequences sense and control cellular physiology.Regulation of bacterial gene expression by ribosome stalling and rescuing.Exploration of the arrest peptide sequence space reveals arrest-enhanced variants.The dynamics of SecM-induced translational stalling.Charge-driven dynamics of nascent-chain movement through the SecYEG transloconRibosome. Mechanical force releases nascent chain-mediated ribosome arrest in vitro and in vivo.SsrA tagging of Escherichia coli SecM at its translation arrest sequence.Prolyl-tRNA(Pro) in the A-site of SecM-arrested ribosomes inhibits the recruitment of transfer-messenger RNA.A biphasic pulling force acts on transmembrane helices during translocon-mediated membrane integration.The Sec System: Protein Export in Escherichia coli.Small protein domains fold inside the ribosome exit tunnel.SuhB is a novel ribosome associated protein that regulates expression of MexXY by modulating ribosome stalling in Pseudomonas aeruginosa.Cotranslational folding of spectrin domains via partially structured states.Origins of the Mechanochemical Coupling of Peptide Bond Formation to Protein Synthesis.Two-step insertion at the SecY translocon.Membrane protein serendipity.
P2860
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P2860
Translocon "pulling" of nascent SecM controls the duration of its translational pause and secretion-responsive secA regulation
description
2003 nî lūn-bûn
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2003年の論文
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年学术文章
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2003年學術文章
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name
Translocon "pulling" of nascen ...... ion-responsive secA regulation
@en
Translocon "pulling" of nascen ...... on-responsive secA regulation.
@nl
type
label
Translocon "pulling" of nascen ...... ion-responsive secA regulation
@en
Translocon "pulling" of nascen ...... on-responsive secA regulation.
@nl
prefLabel
Translocon "pulling" of nascen ...... ion-responsive secA regulation
@en
Translocon "pulling" of nascen ...... on-responsive secA regulation.
@nl
P2093
P2860
P1476
Translocon "pulling" of nascen ...... ion-responsive secA regulation
@en
P2093
Donald B Oliver
Lucia B Prundeanu
Martha E Butkus
P2860
P304
P356
10.1128/JB.185.22.6719-6722.2003
P407
P577
2003-11-01T00:00:00Z