USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex
about
USP22 is a positive regulator of NFATc2 on promoting IL2 expressionUbiquitin signaling in immune responsesTreg functional stability and its responsiveness to the microenvironmentDeubiquitinases: Novel Therapeutic Targets in Immune Surveillance?Molecular characterization of ubiquitin-specific protease 18 reveals substrate specificity for interferon-stimulated gene 15Ubiquitous points of control over regulatory T cells.The E3 deubiquitinase USP17 is a positive regulator of retinoic acid-related orphan nuclear receptor γt (RORγt) in Th17 cellsC-type lectin receptor dectin-3 mediates trehalose 6,6'-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-κB activation.USP18 Sensitivity of Peptide Transporters PEPT1 and PEPT2.USP18 lack in microglia causes destructive interferonopathy of the mouse brain.USP18 negatively regulates NF-κB signaling by targeting TAK1 and NEMO for deubiquitination through distinct mechanisms.Suppression of USP18 Potentiates the Anti-HBV Activity of Interferon Alpha in HepG2.2.15 Cells via JAK/STAT Signaling.TRAF5-mediated Lys-63-linked Polyubiquitination Plays an Essential Role in Positive Regulation of RORγt in Promoting IL-17A ExpressionReversible ubiquitination shapes NLRC5 function and modulates NF-κB activation switchLipopolysaccharide and Tumor Necrosis Factor Alpha Inhibit Interferon Signaling in Hepatocytes by Increasing Ubiquitin-Like Protease 18 (USP18) Expression.Interplay between Inflammation and Stemness in Cancer Cells: The Role of Toll-Like Receptor Signaling.NF-κB Activation in T Helper 17 Cell Differentiation.The emerging roles of deubiquitylating enzymes (DUBs) in the TGFβ and BMP pathways.Structural basis of the specificity of USP18 toward ISG15.Multiple functions of USP18.Post-Translational Modifications of the TAK1-TAB Complex.Ubiquitin enzymes in the regulation of immune responses.Gene expression profile after knockdown of USP18 in Hepg2.2.15 cells.Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex.USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA.Cutting edge: Ubiquitin-specific protease 4 promotes Th17 cell function under inflammation by deubiquitinating and stabilizing RORγt.Contribution of increased ISG15, ISGylation and deregulated type I IFN signaling in Usp18 mutant mice during the course of bacterial infections.Deubiquitylating enzymes and drug discovery: emerging opportunities.USP18 deubiquitinates TAK1:TAB1USP18 protects against hepatic steatosis and insulin resistance through its deubiquitinating activity.USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1
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USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex
description
article científic
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article scientifique
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articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on July 2013
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
USP18 inhibits NF-κB and NFAT ...... tinating the TAK1-TAB1 complex
@en
USP18 inhibits NF-κB and NFAT ...... inating the TAK1-TAB1 complex.
@nl
type
label
USP18 inhibits NF-κB and NFAT ...... tinating the TAK1-TAB1 complex
@en
USP18 inhibits NF-κB and NFAT ...... inating the TAK1-TAB1 complex.
@nl
prefLabel
USP18 inhibits NF-κB and NFAT ...... tinating the TAK1-TAB1 complex
@en
USP18 inhibits NF-κB and NFAT ...... inating the TAK1-TAB1 complex.
@nl
P2093
P2860
P356
P1476
USP18 inhibits NF-κB and NFAT ...... tinating the TAK1-TAB1 complex
@en
P2093
Dong-Er Zhang
Hongxiu Li
Qiang Tian
Sara Gorjestani
P2860
P304
P356
10.1084/JEM.20122327
P407
P577
2013-07-01T00:00:00Z