Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18)
about
Interferon-inducible ubiquitin E2, Ubc8, is a conjugating enzyme for protein ISGylationUbp43 regulates BCR-ABL leukemogenesis via the type 1 interferon receptor signalingCharacterization of alternatively spliced products and tissue-specific isoforms of USP28 and USP25UBP43 (USP18) specifically removes ISG15 from conjugated proteins.High-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction.Ube1L and protein ISGylation are not essential for alpha/beta interferon signaling.Usp18 regulates epidermal growth factor (EGF) receptor expression and cancer cell survival via microRNA-7.Screen for ISG15-crossreactive deubiquitinases.Epstein-Barr virus independent dysregulation of UBP43 expression alters interferon-stimulated gene expression in Burkitt lymphoma.USP18-based negative feedback control is induced by type I and type III interferons and specifically inactivates interferon α response.The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCFSkp2 ubiquitin ligase.Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus.Retinoid target genes in acute promyelocytic leukemia.USP18 Sensitivity of Peptide Transporters PEPT1 and PEPT2.Two independent mechanisms promote expression of an N-terminal truncated USP18 isoform with higher DeISGylation activity in the nucleus.Dysregulation of protein modification by ISG15 results in brain cell injury.USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complexRNA interference screen identifies Usp18 as a regulator of epidermal growth factor receptor synthesis.Interferon-stimulated gene 15 and the protein ISGylation system.STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling.Multiple functions of USP18.USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA.Shuffling of genes within low-copy repeats on 22q11 (LCR22) by Alu-mediated recombination events during evolution.Association of gene expression involving innate immunity and genetic variation in interleukin 28B with antiviral response.Evidence for the ISG15-Specific Deubiquitinase USP18 as an Antineoplastic Target.
P2860
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P2860
Cloning and characterization of a novel human ubiquitin-specific protease, a homologue of murine UBP43 (Usp18)
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2000 nî lūn-bûn
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name
Cloning and characterization o ...... ologue of murine UBP43 (Usp18)
@ast
Cloning and characterization o ...... ologue of murine UBP43 (Usp18)
@en
Cloning and characterization o ...... ologue of murine UBP43 (Usp18)
@en-gb
Cloning and characterization o ...... ologue of murine UBP43 (Usp18)
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type
label
Cloning and characterization o ...... ologue of murine UBP43 (Usp18)
@ast
Cloning and characterization o ...... ologue of murine UBP43 (Usp18)
@en
Cloning and characterization o ...... ologue of murine UBP43 (Usp18)
@en-gb
Cloning and characterization o ...... ologue of murine UBP43 (Usp18)
@nl
prefLabel
Cloning and characterization o ...... ologue of murine UBP43 (Usp18)
@ast
Cloning and characterization o ...... ologue of murine UBP43 (Usp18)
@en
Cloning and characterization o ...... ologue of murine UBP43 (Usp18)
@en-gb
Cloning and characterization o ...... ologue of murine UBP43 (Usp18)
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P2093
P356
P1433
P1476
Cloning and characterization o ...... ologue of murine UBP43 (Usp18)
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P2093
C J Hetherington
M T Little
P356
10.1006/GENO.2000.6148
P407
P577
2000-04-01T00:00:00Z