Identification of sequential viral escape mutants associated with altered T-cell responses in a human immunodeficiency virus type 1-infected individual.
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Inefficient cytotoxic T lymphocyte-mediated killing of HIV-1-infected cells in vivoSwitching and emergence of CTL epitopes in HIV-1 infectionAdaptive interactions between HLA and HIV-1: highly divergent selection imposed by HLA class I molecules with common supertype motifs.Modelling the evolution and spread of HIV immune escape mutantsDynamics of immune escape during HIV/SIV infection.The evolutionary selective advantage of HIV-1 escape variants and the contribution of escape to the HLA-associated risk of AIDS progression.HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins.Timing constraints of in vivo gag mutations during primary HIV-1 subtype C infectionQuantifying the impact of human immunodeficiency virus-1 escape from cytotoxic T-lymphocytes.HIV-1 Transmission, Replication Fitness and Disease Progression.Limited sequence evolution within persistently targeted CD8 epitopes in chronic human immunodeficiency virus type 1 infection.Human immunodeficiency virus mutations during the first month of infection are preferentially found in known cytotoxic T-lymphocyte epitopes.Broad cross-clade T-cell responses to gag in individuals infected with human immunodeficiency virus type 1 non-B clades (A to G): importance of HLA anchor residue conservation.Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolutionVaccination reduces simian-human immunodeficiency virus sequence reversion through enhanced viral controlUpregulation of PD-1 expression on HIV-specific CD8+ T cells leads to reversible immune dysfunction.Characterization of HIV-1 envelope gp41 genetic diversity and functional domains following perinatal transmission.Compensatory substitutions restore normal core assembly in simian immunodeficiency virus isolates with Gag epitope cytotoxic T-lymphocyte escape mutations.Structured observations reveal slow HIV-1 CTL escape.Selection on the human immunodeficiency virus type 1 proteome following primary infection.Positioning of APOBEC3G/F mutational hotspots in the human immunodeficiency virus genome favors reduced recognition by CD8+ T cellsFitness costs and diversity of the cytotoxic T lymphocyte (CTL) response determine the rate of CTL escape during acute and chronic phases of HIV infectionEvolutionary gamut of in vivo Gag substitutions during early HIV-1 subtype C infection.Rapid reversion of sequence polymorphisms dominates early human immunodeficiency virus type 1 evolution.Selection and accumulation of an HIV-1 escape mutant by three types of HIV-1-specific cytotoxic T lymphocytes recognizing wild-type and/or escape mutant epitopes.Effective T-cell responses select human immunodeficiency virus mutants and slow disease progression.Investigating the Consequences of Interference between Multiple CD8+ T Cell Escape Mutations in Early HIV Infection.Emerging complexities of APOBEC3G action on immunity and viral fitness during HIV infection and treatment.Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virusEvolution of human immunodeficiency virus type 1 cytotoxic T-lymphocyte epitopes: fitness-balanced escape.Determinants of human immunodeficiency virus type 1 escape from the primary CD8+ cytotoxic T lymphocyte response.Reduced viral replication capacity of human immunodeficiency virus type 1 subtype C caused by cytotoxic-T-lymphocyte escape mutations in HLA-B57 epitopes of capsid protein.HIV-1 evolution in gag and env is highly correlated but exhibits different relationships with viral load and the immune response.Can non-lytic CD8+ T cells drive HIV-1 escape?Enhancement of viral escape in HIV-1 Nef by STEP vaccination.Lack of in vivo compartmentalization among HIV-1 infected naïve and memory CD4+ T cell subsets.Defining the mechanism(s) of protection by cytolytic CD8 T cells against a cryptic epitope derived from a retroviral alternative reading frame.A human immunodeficiency virus type 1-infected individual with low viral load harbors a virus variant that exhibits an in vitro RNA dimerization defect.The dynamics of HIV-1 adaptation in early infection.Identification of HLA-A*3101-restricted cytotoxic T-lymphocyte response to human immunodeficiency virus type 1 (HIV-1) in patients with chronic HIV-1 infection.
P2860
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P2860
Identification of sequential viral escape mutants associated with altered T-cell responses in a human immunodeficiency virus type 1-infected individual.
description
article científic
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article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2003
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Identification of sequential v ...... us type 1-infected individual.
@en
Identification of sequential v ...... us type 1-infected individual.
@nl
type
label
Identification of sequential v ...... us type 1-infected individual.
@en
Identification of sequential v ...... us type 1-infected individual.
@nl
prefLabel
Identification of sequential v ...... us type 1-infected individual.
@en
Identification of sequential v ...... us type 1-infected individual.
@nl
P2093
P2860
P1433
P1476
Identification of sequential v ...... us type 1-infected individual.
@en
P2093
Fokla Zorgdrager
Hanneke Schuitemaker
John T Dekker
John W Shiver
Jolanda Maas
Kiersten Anderson
Marion Cornelissen
Mark J Geels
P2860
P304
12430-12440
P356
10.1128/JVI.77.23.12430-12440.2003
P407
P577
2003-12-01T00:00:00Z