Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor beta1
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Transforming growth factor {beta} (TGF-{beta})-Smad target gene protein tyrosine phosphatase receptor type kappa is required for TGF-{beta} functionTransforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumabAutocrine PDGFR signaling promotes mammary cancer metastasisHER-2 overexpression differentially alters transforming growth factor-beta responses in luminal versus mesenchymal human breast cancer cellsRebuilding cancer metastasis in the mouseComplexities of TGF-β targeted cancer therapy.TGFbeta in CancerAttenuated transforming growth factor beta signaling promotes metastasis in a model of HER2 mammary carcinogenesisInvolvement of EGF receptor and c-Src in the survival signals induced by TGF-beta1 in hepatocytesRegulation of mammary gland branching morphogenesis by EphA2 receptor tyrosine kinaseDrug development against metastasis-related genes and their pathways: A rationale for cancer therapyA complex containing LPP and α-actinin mediates TGFβ-induced migration and invasion of ErbB2-expressing breast cancer cells.BMP7: a new bone metastases prevention?The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signalingStudies on Xenopus laevis intestine reveal biological pathways underlying vertebrate gut adaptation from embryo to adultConvergence of p53 and transforming growth factor beta (TGFbeta) signaling on activating expression of the tumor suppressor gene maspin in mammary epithelial cells.HER2 in Breast Cancer Stemness: A Negative Feedback Loop towards Trastuzumab Resistance.K-Ras mediated murine epidermal tumorigenesis is dependent upon and associated with elevated Rac1 activityA context-specific role for retinoblastoma protein-dependent negative growth control in suppressing mammary tumorigenesis.Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis.ErbB/EGF signaling and EMT in mammary development and breast cancer.Therapeutic targeting of integrin αvβ6 in breast cancer.Oncogenes and tumor suppressor genesp66ShcA promotes breast cancer plasticity by inducing an epithelial-to-mesenchymal transition.VAMP-associated protein B (VAPB) promotes breast tumor growth by modulation of Akt activity.Gene expression profiling of cancer progression reveals intrinsic regulation of transforming growth factor-beta signaling in ErbB2/Neu-induced tumors from transgenic mice.Angiocrine factors modulate tumor proliferation and motility through EphA2 repression of Slit2 tumor suppressor function in endothelium.Mouse models of breast cancer metastasis.Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression.Hunk is required for HER2/neu-induced mammary tumorigenesis.Context-dependent bidirectional regulation of the MutS homolog 2 by transforming growth factor β contributes to chemoresistance in breast cancer cells.Use of three-dimensional basement membrane cultures to model oncogene-induced changes in mammary epithelial morphogenesis.The Functional Crosstalk between HER2 Tyrosine Kinase and TGF-β Signaling in Breast Cancer Malignancy.A mathematical model quantifies proliferation and motility effects of TGF-β on cancer cells.Extracellular proteolysis in transgenic mouse models of breast cancerMatrix rigidity regulates a switch between TGF-β1-induced apoptosis and epithelial-mesenchymal transition.Pharmacological strategies to overcome HER2 cross-talk and Trastuzumab resistance.The role of microRNA-128a in regulating TGFbeta signaling in letrozole-resistant breast cancer cellsCooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells.Nuclear translocation of type I transforming growth factor β receptor confers a novel function in RNA processing
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Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor beta1
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on December 2003
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Increased malignancy of Neu-in ...... ansforming growth factor beta1
@en
Increased malignancy of Neu-in ...... nsforming growth factor beta1.
@nl
type
label
Increased malignancy of Neu-in ...... ansforming growth factor beta1
@en
Increased malignancy of Neu-in ...... nsforming growth factor beta1.
@nl
prefLabel
Increased malignancy of Neu-in ...... ansforming growth factor beta1
@en
Increased malignancy of Neu-in ...... nsforming growth factor beta1.
@nl
P2093
P2860
P1476
Increased malignancy of Neu-in ...... ansforming growth factor beta1
@en
P2093
Agnieszka E Gorska
Carlos L Arteaga
Dana Brantley-Sieders
L Renee Roebuck
Melinda E Sanders
Rebecca S Muraoka
Yasuhiro Koh
P2860
P304
P356
10.1128/MCB.23.23.8691-8703.2003
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P577
2003-12-01T00:00:00Z