Phthalates impair germ cell development in the human fetal testis in vitro without change in testosterone production. - Wikidata - wikimedia - TriplyDB

Phthalates impair germ cell development in the human fetal testis in vitro without change in testosterone production.

Phthalates impair germ cell development in the human fetal testis in vitro without change in testosterone production.

http://www.wikidata.org/entity/Q37064803

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Teratogenic mechanisms of medical drugs Gene expression in the fetal mouse ovary is altered by exposure to low doses of bisphenol A Xenotransplantation models to study the effects of toxicants on human fetal tissues Proposed role for COUP-TFII in regulating fetal Leydig cell steroidogenesis, perturbation of which leads to masculinization disorders in rodents In utero exposure to di-(2-ethylhexyl) phthalate induces testicular effects in neonatal rats that are antagonized by genistein cotreatment Transcriptional biomarkers of steroidogenesis and trophoblast differentiation in the placenta in relation to prenatal phthalate exposure Differential effects of bisphenol A and diethylstilbestrol on human, rat and mouse fetal leydig cell function Cadmium increases human fetal germ cell apoptosis Maternal Exposure to Domestic Hair Cosmetics and Occupational Endocrine Disruptors Is Associated with a Higher Risk of Hypospadias in the Offspring Nuclear receptors and endocrine disruptors in fetal and neonatal testes: a gapped landscape.Differential response to abiraterone acetate and di-n-butyl phthalate in an androgen-sensitive human fetal testis xenograft bioassay.Human fetal testis xenografts are resistant to phthalate-induced endocrine disruption.Transgenerational effects of di-(2-ethylhexyl) phthalate on testicular germ cell associations and spermatogonial stem cells in mice Signaling pathways in spermatogonial stem cells and their disruption by toxicants Prolonged exposure to acetaminophen reduces testosterone production by the human fetal testis in a xenograft model Xenografting of human fetal testis tissue: a new approach to study fetal testis development and germ cell differentiation.Personal care products and endocrine disruption: A critical review of the literature.Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.A critical assessment of the endocrine susceptibility of the human testis to phthalates from fetal life to adulthood.Similar causes of various reproductive disorders in early life Cellular and molecular effect of MEHP Involving LXRα in human fetal testis and ovary.Urinary phthalate metabolites are associated with decreased serum testosterone in men, women, and children from NHANES 2011-2012.Male Reproductive Disorders and Fertility Trends: Influences of Environment and Genetic Susceptibility.Phthalate esters affect maturation and function of primate testis tissue ectopically grafted in mice An investigation of the endocrine-disruptive effects of bisphenol a in human and rat fetal testes.Comparative effects of di(n-butyl) phthalate exposure on fetal germ cell development in the rat and in human fetal testis xenografts Man is not a big rat: concerns with traditional human risk assessment of phthalates based on their anti-androgenic effects observed in the rat foetus Effects of di(n-butyl) phthalate exposure on foetal rat germ-cell number and differentiation: identification of age-specific windows of vulnerability.Testicular connexin 43, a precocious molecular target for the effect of environmental toxicants on male fertility Gender-Specific Adverse Effects of Mono-Ethylhexyl Phthalate on Steroidogenesis in Immature Granulosa Cells and Rat Leydig cell Progenitors in vitro.Human Chorionic Gonadotropin Partially Mediates Phthalate Association With Male and Female Anogenital Distance.Retracted article: In vitro derivation of mammalian germ cells from stem cells and their potential therapeutic application.Of mice and men (and rats): phthalate-induced fetal testis endocrine disruption is species-dependent.Associations between paternal urinary phthalate metabolite concentrations and reproductive outcomes among couples seeking fertility treatment.Associations between urinary metabolites of di(2-ethylhexyl) phthalate and reproductive hormones in fertile men.Time- and dose-related effects of di-(2-ethylhexyl) phthalate and its main metabolites on the function of the rat fetal testis in vitro.Effect of fetal or neonatal exposure to monobutyl phthalate (MBP) on testicular development and function in the marmoset Phthalates impair germ cell number in the mouse fetal testis by an androgen- and estrogen-independent mechanism Human infertility: are endocrine disruptors to blame?The dynamic epigenetic program in male germ cells: Its role in spermatogenesis, testis cancer, and its response to the environment.

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Phthalates impair germ cell development in the human fetal testis in vitro without change in testosterone production.

http://www.wikidata.org/entity/Q37064803

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scientific article published on 09 September 2008

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Environmental Health Perspectives

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Phthalates impair germ cell de ...... nge in testosterone production

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Catherine Pairault

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Delphine Moison

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Gaëlle Angenard

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Hervé Coffigny

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René Frydman

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René Habert

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Romain Lambrot

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Vincent Muczynski

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Virginie Rouiller-Fabre

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Decrease in anogenital distance among male infants with prenatal phthalate exposure

How strong is the evidence of a link between environmental chemicals and adverse effects on human reproductive health?

Effects of monobutyl and di(n-butyl) phthalate in vitro on steroidogenesis and Leydig cell aggregation in fetal testis explants from the rat: comparison with effects in vivo in the fetal rat and neonatal marmoset and in vitro in the human

Levels of seven urinary phthalate metabolites in a human reference population

Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age

Cryptorchidism in mice mutant for Insl3

The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat

Long-term apoptotic cell death process with increased expression and activation of caspase-3 and -6 in adult rat germ cells exposed in utero to flutamide

Expression of insulin-like factor 3 protein in the rat testis during fetal and postnatal development and in relation to cryptorchidism induced by in utero exposure to di (n-Butyl) phthalate

The role of insulin 3, testosterone, Müllerian inhibiting substance and relaxin in rat gubernacular growth

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32-37

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scholarly article

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10.1289/EHP.11146

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1

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117

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Charlotte Lécureuil

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2008-09-09T00:00:00Z

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23934494

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19165384

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2627862

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