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The role of Dickkopf-1 in bone development, homeostasis, and disease

The role of Dickkopf-1 in bone development, homeostasis, and disease

http://www.wikidata.org/entity/Q37066218

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Emerging Role and Therapeutic Implication of Wnt Signaling Pathways in Autoimmune Diseases Impact of inflammation on the osteoblast in rheumatic diseases Proteomics approaches for the studies of bone metabolism Crystal structures of the extracellular domain of LRP6 and its complex with DKK1 Structures and mechanism for the design of highly potent glucocorticoids Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells Computational modeling of interactions between multiple myeloma and the bone microenvironment Genetic evidence that SOST inhibits WNT signaling in the limb Dickkopf-1 regulates bone formation in young growing rodents and upon traumatic injury Generation and selection of novel fully human monoclonal antibodies that neutralize Dickkopf-1 (DKK1) inhibitory function in vitro and increase bone mass in vivo Increase in Dickkopf-1 Serum Level in Recent Spondyloarthritis. Data from the DESIR Cohort.Increased Dickkopf-1 in Recent-onset Rheumatoid Arthritis is a New Biomarker of Structural Severity. Data from the ESPOIR Cohort Negative regulation of bone formation by the transmembrane Wnt antagonist Kremen-2.Receptor activator of nuclear factor kappa-B ligand (RANKL) but not sclerostin or gene polymorphisms is related to joint destruction in early rheumatoid arthritis.Co-expression of DKK-1 and Sclerostin in Subchondral Bone of the Proximal Femoral Heads from Osteoarthritic Hips Decreased Circulating Levels of Dickkopf-1 in Patients with Exudative Age-related Macular Degeneration Osteoblastogenesis and tumor growth in myeloma.Bone mineral density and serum biochemical predictors of bone loss in patients with CKD on dialysis.Human Dickkopf-1 (huDKK1) protein: characterization of glycosylation and determination of disulfide linkages in the two cysteine-rich domains.Dickkopf-1 is a key regulator of myeloma bone disease: opportunities and challenges for therapeutic intervention Transcriptional silencing of the Wnt-antagonist DKK1 by promoter methylation is associated with enhanced Wnt signaling in advanced multiple myeloma Wnt-related molecules and signaling pathway equilibrium in hematopoiesis.Dickkopf-1 (DKK-1) stimulated prostate cancer growth and metastasis and inhibited bone formation in osteoblastic bone metastases Sclerostin and Dickkopf-1 in renal osteodystrophy.Characterization of the molecular mechanism of the bone-anabolic activity of carfilzomib in multiple myeloma.Serum Dickkopf-1 signaling and calcium deposition in aortic valve are significantly related to the presence of concomitant coronary atherosclerosis in patients with symptomatic calcified aortic stenosis Constitutive activation of IKK2/NF-κB impairs osteogenesis and skeletal development.Investigation of inflammation and tissue patterning in the gut using a Spatially Explicit General-purpose Model of Enteric Tissue (SEGMEnT).Molecular changes in pre-metastatic lymph nodes of esophageal cancer patients.Bone healing: little secrets.The PCa Tumor Microenvironment.Wnt/Β-catenin and sex hormone signaling in endometrial homeostasis and cancer.Dickkopf1: a tumor suppressor or metastasis promoter?Metastatic breast cancer cells inhibit osteoblast differentiation through the Runx2/CBFβ-dependent expression of the Wnt antagonist, sclerostin.The Wnt inhibitor dickkopf-1: a link between breast cancer and bone metastases.Activation of canonical Wnt signalling is required for TGF-β-mediated fibrosis.Update on Wnt signaling in bone cell biology and bone disease.High Parathyroid Hormone Level and Osteoporosis Predict Progression of Coronary Artery Calcification in Patients on Dialysis.Effects of Combined Exposure to Lead and High-Fat Diet on Bone Quality in Juvenile Male Mice Calycosin-7-O-β-d-glucopyranoside stimulates osteoblast differentiation through regulating the BMP/WNT signaling pathways

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The role of Dickkopf-1 in bone development, homeostasis, and disease

http://www.wikidata.org/entity/Q37066218

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

@pt

bilimsel makale

@tr

scientific article published on 07 August 2008

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

The role of Dickkopf-1 in bone development, homeostasis, and disease

@en

The role of Dickkopf-1 in bone development, homeostasis, and disease.

@nl

type

label

The role of Dickkopf-1 in bone development, homeostasis, and disease

@en

The role of Dickkopf-1 in bone development, homeostasis, and disease.

@nl

prefLabel

The role of Dickkopf-1 in bone development, homeostasis, and disease

@en

The role of Dickkopf-1 in bone development, homeostasis, and disease.

@nl

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BLOOD-2008-03-145169

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The role of Dickkopf-1 in bone development, homeostasis, and disease

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Brett M Hall

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John D Shaughnessy

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Joseph J Pinzone

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Martin Vonau

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Nanda K Thudi

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P2860

A new secreted protein that binds to Wnt proteins and inhibits their activities

Inhibition of adipogenesis by Wnt signaling

Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis

Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait

Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro

Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing

Wnt/beta-catenin signaling in development and disease

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517-525

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10.1182/BLOOD-2008-03-145169

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Thomas J. Rosol

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2628360

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