Landscape of the mitochondrial Hsp90 metabolome in tumours
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Cancer cells exploit adaptive mitochondrial dynamics to increase tumor cell invasionPI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion.Survivin promotes oxidative phosphorylation, subcellular mitochondrial repositioning, and tumor cell invasionA neuronal network of mitochondrial dynamics regulates metastasis.TRAP1 regulates proliferation, mitochondrial function, and has prognostic significance in NSCLC.TRAP1 protein signature predicts outcome in human metastatic colorectal carcinoma.Anti-cancer potential of MAPK pathway inhibition in paragangliomas-effect of different statins on mouse pheochromocytoma cells.Mitochondrial Hsp90s suppress calcium-mediated stress signals propagating from mitochondria to the ER in cancer cellsCombination treatment with doxorubicin and gamitrinib synergistically augments anticancer activity through enhanced activation of Bim.Deletion of the mitochondrial chaperone TRAP-1 uncovers global reprogramming of metabolic networks.N-terminal functional domain of Gasdermin A3 regulates mitochondrial homeostasis via mitochondrial targeting.Structural basis of Sorcin-mediated calcium-dependent signal transductionAdaptive mitochondrial reprogramming and resistance to PI3K therapy.The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis.Protein Co-Expression Analysis as a Strategy to Complement a Standard Quantitative Proteomics Approach: Case of a Glioblastoma Multiforme Study.Deletion of Cyclophilin D Impairs β-Oxidation and Promotes Glucose MetabolismDisabling mitochondrial reprogramming in cancerTranscriptomic and Proteomic Investigation of HSP90A as a Potential Biomarker for HCC.Molecular Pathways: Mitochondrial Reprogramming in Tumor Progression and Therapy.Chemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease.Aberrantly upregulated TRAP1 is required for tumorigenesis of breast cancer.Hypoxia potentiates the cytotoxic effect of piperlongumine in pheochromocytoma models.TRAP1: a viable therapeutic target for future cancer treatments?Transgenic Expression of the Mitochondrial Chaperone TNFR-associated Protein 1 (TRAP1) Accelerates Prostate Cancer Development.Nutrient Sensing and the Oxidative Stress Response.Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes.Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitorsTRAP1-dependent regulation of p70S6K is involved in the attenuation of protein synthesis and cell migration: relevance in human colorectal tumorsMitochondria on the move: emerging paradigms of organelle trafficking in tumour plasticity and metastasis.The diverse lives of TRAP1.Pheochromocytoma: The First Metabolic Endocrine Cancer.TRAP1 regulates stemness through Wnt/β-catenin pathway in human colorectal carcinomaSyntaphilin controls a mitochondrial rheostat for proliferation-motility decisions in cancer.Inhibition of Mitochondrial Matrix Chaperones and Antiapoptotic Bcl-2 Family Proteins Empower Antitumor Therapeutic Responses.Leveraging ectopic Hsp90 expression to assay the presence of tumor cells and aggressive tumor phenotypes in breast specimens.Cooperation between Hsp90 and mortalin/GRP75 in resistance to cell death induced by complement C5b-9.TRAP1 controls cell cycle G2-M transition through the regulation of CDK1 and MAD2 expression/ubiquitination.A Mitochondrial-targeted purine-based HSP90 antagonist for leukemia therapy.Hsp90β knockdown in DIO mice reverses insulin resistance and improves glucose tolerance.The diagnostic value of tumor markers in bronchoalveolar lavage fluid for the peripheral pulmonary carcinoma.
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Landscape of the mitochondrial Hsp90 metabolome in tumours
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2013
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Landscape of the mitochondrial Hsp90 metabolome in tumours
@en
Landscape of the mitochondrial Hsp90 metabolome in tumours.
@nl
type
label
Landscape of the mitochondrial Hsp90 metabolome in tumours
@en
Landscape of the mitochondrial Hsp90 metabolome in tumours.
@nl
prefLabel
Landscape of the mitochondrial Hsp90 metabolome in tumours
@en
Landscape of the mitochondrial Hsp90 metabolome in tumours.
@nl
P2093
P2860
P356
P1476
Landscape of the mitochondrial Hsp90 metabolome in tumours
@en
P2093
Alessia Angelin
Andrew V Kossenkov
Arthur S Tischler
Dario C Altieri
David W Speicher
Douglas C Wallace
Edward D Karoly
James F Powers
Kaye D Speicher
P2860
P2888
P356
10.1038/NCOMMS3139
P407
P50
P577
2013-01-01T00:00:00Z