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Modeling the temporal evolution of the spindle assembly checkpoint and role of Aurora B kinase

Modeling the temporal evolution of the spindle assembly checkpoint and role of Aurora B kinase

http://www.wikidata.org/entity/Q37068566

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Reverse engineering of the spindle assembly checkpoint Aurora-C kinase deficiency causes cytokinesis failure in meiosis I and production of large polyploid oocytes in mice.Stage I of a phase 2 study assessing the efficacy, safety, and tolerability of barasertib (AZD1152) versus low-dose cytosine arabinoside in elderly patients with acute myeloid leukemia.Using default constraints of the spindle assembly checkpoint to estimate the associated chemical rates.Pharmacodynamic modelling of biomarker data in oncology.Phase 1/2 study to assess the safety, efficacy, and pharmacokinetics of barasertib (AZD1152) in patients with advanced acute myeloid leukemia.Phase I study of the Aurora B kinase inhibitor barasertib (AZD1152) to assess the pharmacokinetics, metabolism and excretion in patients with acute myeloid leukemia.Modelling of the cancer cell cycle as a tool for rational drug development: A systems pharmacology approach to cyclotherapy.Erroneous Silencing of the Mitotic Checkpoint by Aberrant Spindle Pole-Kinetochore Coordination.A quantitative systems view of the spindle assembly checkpoint.Novel drugs for older patients with acute myeloid leukemia.In silico spatial simulations reveal that MCC formation and excess BubR1 are required for tight inhibition of the anaphase-promoting complex.Spindle assembly checkpoint is sufficient for complete Cdc20 sequestering in mitotic control.Systems Biology Modeling of Five Pathways for Regulation and Potent Inhibition of the Anaphase-Promoting Complex (APC/C): Pivotal Roles for MCC and BubR1.A Dynamical Model for Activating and Silencing the Mitotic Checkpoint The mitotic checkpoint complex (MCC): looking back and forth after 15 years.Active transport can greatly enhance Cdc20:Mad2 formation.Dynamical scenarios for chromosome bi-orientation.Mitotic Kinases and p53 Signaling.Modeling the mitotic regulatory network identifies highly efficient anti-cancer drug combinations.A Mathematical Framework for Kinetochore-Driven Activation Feedback in the Mitotic Checkpoint.Stochastic modelling of chromosomal segregation: errors can introduce correction.A phase II trial of AZD1152 in relapsed/refractory diffuse large B-cell lymphoma.

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Modeling the temporal evolution of the spindle assembly checkpoint and role of Aurora B kinase

http://www.wikidata.org/entity/Q37068566

description

article científic

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article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

@tr

scientific article published on 17 December 2008

@en

vedecký článok

@sk

vetenskaplig artikel

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videnskabelig artikel

@da

vědecký článek

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name

Modeling the temporal evolutio ...... nt and role of Aurora B kinase

@en

Modeling the temporal evolutio ...... t and role of Aurora B kinase.

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type

label

Modeling the temporal evolutio ...... nt and role of Aurora B kinase

@en

Modeling the temporal evolutio ...... t and role of Aurora B kinase.

@nl

prefLabel

Modeling the temporal evolutio ...... nt and role of Aurora B kinase

@en

Modeling the temporal evolutio ...... t and role of Aurora B kinase.

@nl

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PNAS.0810706106

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Proceedings of the National Academy of Sciences of the United States of America

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Modeling the temporal evolutio ...... nt and role of Aurora B kinase

@en

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David E MacCallum

http://www.w3.org/2001/XMLSchema#string

Robert C Jackson

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P2860

Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase

Dynamic instability of microtubules as an efficient way to search in space

The checkpoint delaying anaphase in response to chromosome monoorientation is mediated by an inhibitory signal produced by unattached kinetochores

The small molecule Hesperadin reveals a role for Aurora B in correcting kinetochore-microtubule attachment and in maintaining the spindle assembly checkpoint

Kinetochore fiber maturation in PtK1 cells and its implications for the mechanisms of chromosome congression and anaphase onset

Exploring the functional interactions between Aurora B, INCENP, and survivin in mitosis

Structural activation of Mad2 in the mitotic spindle checkpoint: the two-state Mad2 model versus the Mad2 template model

Chromosomes can congress to the metaphase plate before biorientation.

The spindle-assembly checkpoint in space and time

The Ipl1-Aurora protein kinase activates the spindle checkpoint by creating unattached kinetochores.

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20215-20220

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scholarly article

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10.1073/PNAS.0810706106

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51

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105

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Hitesh B Mistry

Fordyce A. Davidson

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2008-12-17T00:00:00Z

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23672993

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19091947

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2629297

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